ArticleGut1992
Diminished expression of integrin adhesion molecules on human colonic epithelial cells during the benign to malign tumour transformation.
Article in Gut, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 154 citations in OpenAlex.
- Article
- Identification of a Favorable Prognostic Subgroup in Oral Squamous Cell Carcinoma: Characterization of ITGB4/PD-L1Biomolecules · 2023Article
- Revising the Role of Integrin Subunit β4 Expression in Colon Cancer Progression and Survival.Journal of gastrointestinal cancer · 2023Article
- ITGB4 as a novel serum diagnosis biomarker and potential therapeutic target for colorectal cancer.Cancer medicine · 2021Article
- Fully synthetic matrices for in vitro culture of primary human intestinal enteroids and endometrial organoids.Biomaterials · 2020Article
- Integrin α6β4 in Colorectal Cancer: Expression, Regulation, Functional Alterations and Use as a Biomarker.Cancers · 2019Review
- Extracellular Vesicle Integrins Distinguish Unique Cancers.Proteomes · 2019Article
- Combined epithelial marker analysis of tumour budding in stage II colorectal cancer.The journal of pathology. Clinical research · 2019Article
- ITGB4 is a novel prognostic factor in colon cancer.Journal of Cancer · 2019Article
- Molecular characterization of pro-metastatic functions of β4-integrin in colorectal cancer.Oncotarget · 2017Article
- Article
- Clustering of integrin α5 at the lateral membrane restores epithelial polarity in invasive colorectal cancer cells.Molecular biology of the cell · 2017Article
- Bile acid: a potential inducer of colon cancer stem cells.Stem cell research & therapy · 2016Article
- Role of cancer stem cells in racial disparity in colorectal cancer.Cancer medicine · 2016Article
- Clinical significance of the integrin α6β4 in human malignancies.Laboratory investigation; a journal of technical methods and pathology · 2015Review
- Impairement of HT29 Cancer Cells Cohesion by the Soluble Form of Neurotensin Receptor-3.Genes & cancer · 2014Article
- Article
- Prognostic value of β1 integrin expression in colorectal liver metastases.International journal of clinical and experimental pathology · 2014Article
- Expression profiling using a cDNA array and immunohistochemistry for the extracellular matrix genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in colorectal carcinoma progression and dissemination.TheScientificWorldJournal · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Integrins are transmembrane molecules that mediate cell-cell and cell-substratum adhesion. Because alterations in the adhesive properties of tumour cells are thought to influence tumour cell invasion, the expression of integrin alpha and beta chains in 19 human colorectal carcinomas, eight adenomas, and eight normal colon tissues was examined immunohistochemically using an indirect immunofluorescent technique. Normal colonic epithelial cells were found to express the integrin alpha 3, alpha 5, alpha 6, beta 1, and beta 4 chains, whereas the alpha 2 chain was expressed only on epithelial cells lining the base of the crypts and was absent from cells lining the mouth of the crypts or the surface epithelium. No epithelial staining of the alpha 1, alpha 4, beta 2, and beta 3 chains was observed. A progressive reduction of all normally expressed alpha and beta chains was associated with increasing neoplastic transformation. The expression of the alpha 3 and alpha 5 chains was already noticeably reduced in adenomas, and was completely absent in most colonic carcinomas. In contrast, alpha 6, beta 1, and beta 4 expression was maintained in adenomas, whereas the transformation from benign to malignant neoplasms associated with infiltrative growth was characterised by diminished or lost expression of alpha 6, beta 1, and beta 4 chains. Thus, the decreased expression of integrins in human colon carcinomas may contribute to the altered adhesion and migration properties of these tumour cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.