Evidence map›Paper›PMID 15686100›Full record

ArticleCerebellum (London, England)2004

Immunohistochemical localization of cannabinoid CB1 receptor in inhibitory interneurons in the cerebellum.

John C Ashton, Ian Appleton, Cynthia L Darlington, Paul F Smith

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Cerebellum (London, England), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. The Role of Neuroligins in the Cerebellum Highlights the Diversity of Synapse-Specifying Molecules.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Cannabis use disrupts eyeblink conditioning: evidence for cannabinoid modulation of cerebellar-dependent learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2008
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

John C AshtonDepartment of Pharmacology and Toxicology, School of Medical Sciences, University of Otago Medical School, University of Otago, Dunedin, New Zealand. john.ashton@stonebow.otago.ac.nz
Ian Appleton
Cynthia L Darlington
Paul F Smith
University of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inhibitory interneurons terminating on Purkinje cell dendrites contribute to cannabinoid-mediated cerebellar plasticity, consistent with the intense expression of cannabinoid CB1 receptor protein in the cerebellar molecular layer. CB1 labelling in the molecular layer has been attributed to parallel fibers originating from granule cells, climbing fibers originating in the inferior olive, and inhibitory interneurons in the deep molecular layer (basket cells). However, the cellular distribution of CB1 in the cerebellar molecular layer has remained poorly understood. We used double fluorescence labelling to test for co-localization of nuclei with CB1 receptor protein. Labelling was intense surrounding nuclei in the deep and superficial molecular layer; consistent with basket cell and stellate cell inhibitory interneurons that regulate depolarization-induced suppression of inhibition (DSI) of Purkinje cells.

Indexed as

AnimalsBenzimidazolesCerebellumImmunohistochemistryInterneuronsMaleNeural InhibitionRatsRats, WistarReceptor, Cannabinoid, CB1Benzimidazolesbisbenzimide ethoxide trihydrochlorideReceptor, Cannabinoid, CB1

Identifiers

PMID15686100
OpenAlexW2019969132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.