ArticleBehavior genetics2005
Lineage is an epigenetic modifier of QTL influencing behavioral coping with stress.
Article in Behavior genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Paternal inheritance of a vulnerable opioid-taking phenotype in female rats.bioRxiv : the preprint server for biology · 2026Article
- Limited WKY chromosomal regions confer increases in anxiety and fear memory in a F344 congenic rat strain.Physiological genomics · 2024Article
- Hunting for Genes Underlying Emotionality in the Laboratory Rat: Maps, Tools and Traps.Current neuropharmacology · 2023Review
- The Wistar Kyoto Rat: A Model of Depression Traits.Current neuropharmacology · 2023Article
- Heterogeneous stock rats: a model to study the genetics of despair-like behavior in adolescence.Genes, brain, and behavior · 2018Article
- Article
- Prenatal thyroxine treatment disparately affects peripheral and amygdala thyroid hormone levels.Psychoneuroendocrinology · 2010Article
- Antidepressant-like effects of kappa-opioid receptor antagonists in Wistar Kyoto rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- Context and strain-dependent behavioral response to stress.Behavioral and brain functions : BBF · 2008Article
- Test- and behavior-specific genetic factors affect WKY hypoactivity in tests of emotionality.Behavioural brain research · 2006Article
- Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- mice.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Sex- and lineage-specific inheritance of depression-like behavior in the rat.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
A genome-wide scan was carried out on a segregating F2 population of rats derived from reciprocal intercrosses between two inbred strains of rats, Fisher 344 (F344) and Wistar Kyoto (WKY) that differ significantly in their behavioral coping responses to stress measured by the defensive burying (DB) test. The DB test measures differences in coping strategies by assaying an animal's behavioral response to an immediate threat. We have previously identified three X-linked loci contributing to the phenotypic variance in behavioral coping. Here we report on six significant autosomal quantitative trait loci (QTL) related to different behaviors in the DB test:one for the number of shocks received, three for number of prod approaches, one for latency to bury, and one pleiotropic locus affecting both approach and latency. These QTL contributing to different aspects of coping behaviors show that the effect of genotype on phenotype is highly dependent on lineage. The WKY lineage was particularly influential, with five out of the six QTL affecting coping behavior only in rats of the WKY lineage, and one locus affecting only those in the F344 lineage. Thus, epigenetic factors, primarily of WKY origin, may significantly modulate the genetic contribution to variance in behavioral responses to stress in the DB test.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.