ArticleMolecular and cellular biology2005
Cdx protein interaction with Hoxa5 regulatory sequences contributes to Hoxa5 regional expression along the axial skeleton.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Loss of Hoxa5 function affects Hox gene expression in different biological contexts.Scientific reports · 2024Article
- Identification of a Chondrocyte-Specific Enhancer in theJournal of developmental biology · 2024Article
- Characterising open chromatin in chick embryos identifies cis-regulatory elements important for paraxial mesoderm formation and axis extension.Nature communications · 2021Article
- HOX gene cluster (de)regulation in brain: from neurodevelopment to malignant glial tumours.Cellular and molecular life sciences : CMLS · 2020Review
- MicroRNA-181d-5p-Containing Exosomes Derived from CAFs Promote EMT by Regulating CDX2/HOXA5 in Breast Cancer.Molecular therapy. Nucleic acids · 2020Article
- Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs.Cell death & disease · 2019Article
- Hoxa5: A Key Player in Development and Disease.Journal of developmental biology · 2016Review
- Article
- YY1 acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis.PloS one · 2014Article
- Genome-wide in silico identification of new conserved and functional retinoic acid receptor response elements (direct repeats separated by 5 bp).The Journal of biological chemistry · 2011Article
- Epigenetic regulations in hematopoietic Hox code.Oncogene · 2011Review
- Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3.Molecular and cellular biology · 2010Article
- Hox genes and regional patterning of the vertebrate body plan.Developmental biology · 2010Review
- Multiple promoters and alternative splicing: Hoxa5 transcriptional complexity in the mouse embryo.PloS one · 2010Article
- The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis.The Journal of clinical investigation · 2007Article
- cis-Decoder discovers constellations of conserved DNA sequences shared among tissue-specific enhancers.Genome biology · 2007Article
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Hox gene functions are intimately linked to correct developmental expression of the genes. The identification of cis-acting regulatory sequences and their associated trans-acting factors constitutes a key step in deciphering the mechanisms underlying the correct positioning of the functional domain of Hox genes along the anterior-posterior axis. We have identified DNA elements driving Hoxa5 regionalized expression in mice, using the 2.1-kb mesodermal enhancer (MES) localized in Hoxa5 3' flanking sequences as a starting point. The MES sequence comprises regulatory elements targeting Hoxa5 expression in the limbs, the urogenital and gastrointestinal tracts, and the cervical-upper thoracic region of the prevertebral column. A 164-bp DNA fragment within the MES caudally restricts Hoxa5 expression at the level of prevertebra 10, corresponding to the posterior limit of its functional domain. Cdx proteins directly bind to this element in vitro via two conserved sites. Preventing Cdx binding by mutating the sites causes caudal expansion of the transgene expression domain. Of all three murine Cdx proteins that bind this element in vitro, Cdx4 has emerged as a potential regional posterior repressor of Hoxa5 expression. The restrictive control provided by Cdx interactions with Hoxa5 regulatory sequences may be one of the critical events in cervicothoracic axial specification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.