ArticleProceedings of the National Academy of Sciences of the United States of America2005
Characterizing functional hippocampal pathways in a brain-based device as it solves a spatial memory task.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Compositional neurosymbolic representations enable efficient active exploration.Nature communications · 2026Article
- Design Principles for Neurorobotics.Frontiers in neurorobotics · 2022Article
- Neurobiologically Inspired Self-Monitoring Systems.Proceedings of the IEEE. Institute of Electrical and Electronics Engineers · 2020Article
- Neurorobots as a Means Toward Neuroethology and Explainable AI.Frontiers in neurorobotics · 2020Review
- Neurorobotics-A Thriving Community and a Promising Pathway Toward Intelligent Cognitive Robots.Frontiers in neurorobotics · 2018Article
- A Computational Model for Spatial Navigation Based on Reference Frames in the Hippocampus, Retrosplenial Cortex, and Posterior Parietal Cortex.Frontiers in neurorobotics · 2017Article
- Unlocking neural complexity with a robotic key.The Journal of physiology · 2016Review
- The measurement of consciousness: a framework for the scientific study of consciousness.Frontiers in psychology · 2014Article
- Three tools for the real-time simulation of embodied spiking neural networks using GPUs.Neuroinformatics · 2013Article
- From baconian to popperian neuroscience.Neural systems & circuits · 2012Article
- Adult neurogenesis: integrating theories and separating functions.Trends in cognitive sciences · 2010Review
- Causal networks in simulated neural systems.Cognitive neurodynamics · 2008Article
- Order in spontaneous behavior.PloS one · 2007Article
- Retrospective and prospective responses arising in a modeled hippocampus during maze navigation by a brain-based device.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- A cerebellar model for predictive motor control tested in a brain-based device.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Spatial navigation and causal analysis in a brain-based device modeling cortical-hippocampal interactions.Neuroinformatics · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Analyzing neural dynamics underlying complex behavior is a major challenge in systems neurobiology. To meet this challenge through computational neuroscience, we have constructed a brain-based device (Darwin X) that interacts with a real environment, and whose behavior is guided by a simulated nervous system incorporating detailed aspects of the anatomy and physiology of the hippocampus and its surrounding regions. Darwin X integrates cues from its environment to solve a spatial memory task. Place-specific units, similar to place cells in the rodent, emerged by integrating visual and self-movement cues during exploration without prior assumptions in the model about environmental inputs. Because synthetic neural modeling using brain-based devices allows recording from all elements of the simulated nervous system during behavior, we were able to identify different functional hippocampal pathways. We did this by tracing back from reference neuronal units in the CA1 region of the simulated hippocampus to all of the synaptically connected units that were coactive during a particular exploratory behavior. Our analysis identified a number of different functional pathways within the simulated hippocampus that incorporate either the perforant path or the trisynaptic loop. Place fields, which were activated by the trisynaptic circuit, tended to be more selective and informative. However, place units that were activated by the perforant path were prevalent in the model and were crucial for generating appropriate exploratory behavior. Thus, in the model, different functional pathways influence place field activity and, hence, behavior during navigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.