ArticleThe Journal of cell biology2005
Myosin V attachment to cargo requires the tight association of two functional subdomains.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Structural mechanism for versatile cargo recognition by the yeast class V myosin Myo2.The Journal of biological chemistry · 2019Article
- Identification of the Isoform-specific Interactions between the Tail and the Head of Class V Myosin.The Journal of biological chemistry · 2016Article
- Processing-body movement in Arabidopsis depends on an interaction between myosins and DECAPPING PROTEIN1.Plant physiology · 2014Article
- Structural insights into functional overlapping and differentiation among myosin V motors.The Journal of biological chemistry · 2013Article
- Myosin XIK is a major player in cytoplasm dynamics and is regulated by two amino acids in its tail.Journal of experimental botany · 2012Article
- The myosin-related motor protein Myo2 is an essential mediator of bud-directed mitochondrial movement in yeast.The Journal of cell biology · 2011Article
- Whole-genome SNP association in the horse: identification of a deletion in myosin Va responsible for Lavender Foal Syndrome.PLoS genetics · 2010Article
- Myosin-driven peroxisome partitioning in S. cerevisiae.The Journal of cell biology · 2009Article
- Systematic definition of protein constituents along the major polarization axis reveals an adaptive reuse of the polarization machinery in pheromone-treated budding yeast.Journal of proteome research · 2009Article
- The role of actin remodeling in the trafficking of intracellular vesicles, transporters, and channels: focusing on aquaporin-2.Pflugers Archiv : European journal of physiology · 2008Review
- Pushing for answers: is myosin V directly involved in moving mitochondria?The Journal of cell biology · 2008Article
- The class V myosin motor protein, Myo2, plays a major role in mitochondrial motility in Saccharomyces cerevisiae.The Journal of cell biology · 2008Article
- Myo4p is a monomeric myosin with motility uniquely adapted to transport mRNA.The Journal of cell biology · 2007Article
- Acto-Myosin motorises the flow of auxin.Plant signaling & behavior · 2007Article
- Regulating cytoskeleton-based vesicle motility.FEBS letters · 2007Review
- Regulated phosphorylation of budding yeast's essential myosin V heavy chain, Myo2p.Molecular biology of the cell · 2006Article
- Structural basis for myosin V discrimination between distinct cargoes.The EMBO journal · 2006Article
- A point mutation in the cargo-binding domain of myosin V affects its interaction with multiple cargoes.Eukaryotic cell · 2005Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The myosin V carboxyl-terminal globular tail domain is essential for the attachment of myosin V to all known cargoes. Previously, the globular tail was viewed as a single, functional entity. Here, we show that the globular tail of the yeast myosin Va homologue, Myo2p, contains two structural subdomains that have distinct functions, namely, vacuole-specific and secretory vesicle-specific movement. Biochemical and genetic analyses demonstrate that subdomain I tightly associates with subdomain II, and that the interaction does not require additional proteins. Importantly, although neither subdomain alone is functional, simultaneous expression of the separate subdomains produces a functional complex in vivo. Our results suggest a model whereby intramolecular interactions between the globular tail subdomains help to coordinate the transport of multiple distinct cargoes by myosin V.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.