ArticleComparative biochemistry and physiology. Toxicology & pharmacology : CBP2004
Pharmacology and toxicology of pahayokolide A, a bioactive metabolite from a freshwater species of Lyngbya isolated from the Florida Everglades.
Article in Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 86 citations in OpenAlex.
- Natural Products That Contain Higher Homologated Amino Acids.Chembiochem : a European journal of chemical biology · 2024Review
- A Review of the Antimicrobial Properties of Cyanobacterial Natural Products.Molecules (Basel, Switzerland) · 2023Review
- Cyanobacteria: A Promising Source of Antifungal Metabolites.Marine drugs · 2023Review
- Influence of Low Salt Concentration on Growth Behavior and General Biomass Composition inMarine drugs · 2020Article
- Natural Products from Cyanobacteria: Focus on Beneficial Activities.Marine drugs · 2019Review
- Evaluation of Various Biological Activities of the Aerial Parts ofIranian journal of pharmaceutical research : IJPR · 2017Article
- α,β-Dehydroamino acids in naturally occurring peptides.Amino acids · 2015Review
- Indole alkaloids from Fischerella inhibit vertebrate development in the zebrafish (Danio rerio) embryo model.Toxins · 2014Article
- Biosynthesis of Athmu, a α,γ-hydroxy-β-amino acid of pahayokolides A-B.Tetrahedron letters · 2012Article
- Polymethoxy-1-alkenes from Aphanizomenon ovalisporum inhibit vertebrate development in the zebrafish (Danio rerio) embryo model.Marine drugs · 2012Article
- Chemodiversity in freshwater and terrestrial cyanobacteria - a source for drug discovery.Current drug targets · 2011Review
- Unraveling cyanobacteria ecology in wastewater treatment plants (WWTP).Microbial ecology · 2011Review
- Biosynthetic origin of the 3-amino-2,5,7,8-tetrahydroxy-10-methylundecanoic acid moiety and absolute configuration of pahayokolides A and B.Journal of natural products · 2011Article
- Synergistic allelochemicals from a freshwater cyanobacterium.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- New peptides isolated from Lyngbya species: a review.Marine drugs · 2010Review
- Cyanobacterial toxins as allelochemicals with potential applications as algaecides, herbicides and insecticides.Marine drugs · 2008Review
- Allelopathic activity among Cyanobacteria and microalgae isolated from Florida freshwater habitats.FEMS microbiology ecology · 2008Article
- Structures of pahayokolides A and B, cyclic peptides from a Lyngbya sp.Journal of natural products · 2007Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The genus of filamentous cyanobacteria, Lyngbya, has been found to be a rich source of bioactive metabolites. However, identification of such compounds from Lyngbya has largely focused on a few marine representatives. Here, we report on the pharmacology and toxicology of pahayokolide A from a freshwater isolate, Lyngbya sp. strain 15-2, from the Florida Everglades. Specifically, we investigated inhibition of microbial representatives and mammalian cell lines, as well as toxicity of the compound to both invertebrate and vertebrate models. Pahayokolide A inhibited representatives of Bacillus, as well as the yeast, Saccharomyces cerevisiae. Interestingly, the compound also inhibited several representatives of green algae that were also isolated from the Everglades. Pahayokolide A was shown to inhibit a number of cancer cell lines over a range of concentrations (IC50 varied from 2.13 to 44.57 microM) depending on the cell-type. When tested against brine shrimp, pahayokolide was only marginally toxic at the highest concentrations tested (1 mg/mL). The compound was, however, acutely toxic to zebrafish embryos (LC50=2.15 microM). Possible biomedical and environmental health aspects of the pahayokolides remain to be investigated; however, the identification of bioactive metabolites such as these demonstrates the potential of the Florida Everglades as source of new toxins and drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.