ReviewCurrent atherosclerosis reports2005
Rationale for combination therapy with statin drugs in the treatment of dyslipidemia.
Review in Current atherosclerosis reports, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00203476. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Open Label Comparison of Ezetimibe, Niacin, and Colestipol as Adjunct Therapy in Lipid Reduction
Open the trial in the graphWho cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative Lipid-Lowering/Increasing Efficacy of 7 Statins in Patients with Dyslipidemia, Cardiovascular Diseases, or Diabetes Mellitus: Systematic Review and Network Meta-Analyses of 50 Randomized Controlled Trials.Cardiovascular therapeutics · 2020 · on this mapPooled it
- Article
- JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs.BMC cardiovascular disorders · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although statin therapy is a mainstay of lipid treatment, complementary effects of other cholesterol-lowering therapies modify the lipid panel and other aspects of coronary disease risk. These other therapies lower low-density lipoprotein cholesterol and triglycerides and/or raise high-density lipoprotein cholesterol, improve diabetic control, and modify other cardiovascular risks. Historically, combination therapy has been reserved for the small minority of patients with severe dyslipidemia, due to perceived risk. More recently, however, it has been recognized that the potential complications of this combination are far outweighed by the clinical benefits that are possible.
Indexed as
Identifiers
15683599What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.