ReviewCurrent hypertension reports2005
Admixture mapping as a gene discovery approach for complex human traits and diseases.
Review in Current hypertension reports, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Inference of human continental origin and admixture proportions using a highly discriminative ancestry informative 41-SNP panel.Investigative genetics · 2013Article
- Admixture mapping to identify spontaneous preterm birth susceptibility loci in African Americans.Obstetrics and gynecology · 2011Article
- Peptide YY (PYY) gene polymorphisms in the 3'-untranslated and proximal promoter regions regulate cellular gene expression and PYY secretion and metabolic syndrome traits in vivo.The Journal of clinical endocrinology and metabolism · 2009Article
- Admixture mapping provides evidence of association of the VNN1 gene with hypertension.PloS one · 2007Article
- A genomewide admixture mapping panel for Hispanic/Latino populations.American journal of human genetics · 2007Article
- Admixture in Mexico City: implications for admixture mapping of type 2 diabetes genetic risk factors.Human genetics · 2007Article
- Statistical genetics concepts and approaches in schizophrenia and related neuropsychiatric research.Schizophrenia bulletin · 2007Review
- Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear model.PLoS genetics · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Admixture mapping (AM) is a special form of conventional meiotic or recombination mapping for disease gene discovery in humans that exploits naturally occurring genetic and phenotypic differences existing in populations between which recent gene flow has occurred. Essentially, mates from two different "parental" populations with different allelic and disease-predisposing mutation profiles will produce "admixed" offspring whose genomes will be mixtures of the genomes associated with the parental populations. Strong linkage disequilibrium (LD) will exist for several generations between neighboring loci of admixed individuals and can be exploited for identifying the genomic location of trait-influencing loci. Although it may be a very clever strategy for identifying genes that influence human traits and diseases, AM can be problematic. We review the foundations, basic strategies, resources, and settings necessary for AM. We conclude that AM has potential in the identification of disease-predisposing loci, but this potential may only exist in a limited number of realistic settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.