ArticleWorld journal of gastroenterology2005
Clinical significance of matrix metalloproteinase-9 expression in esophageal squamous cell carcinoma.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 37 citations in OpenAlex.
- Lower Serum Matrix Metalloproteinase‑9 in Metastatic Patients with Esophageal Squamous Cell Carcinoma After Concurrent Radiotherapy Was Significant for Prognosis.OncoTargets and therapy · 2020Article
- Can MMP-9 be a Prognosticator Marker for Oral Squamous Cell Carcinoma?Journal of clinical and diagnostic research : JCDR · 2016Article
- Silencing of CXCR2 and CXCR7 protects against esophageal cancer.American journal of translational research · 2016Article
- Molecular alterations and clinical relevance in esophageal squamous cell carcinoma.Frontiers of medicine · 2013Review
- EMMPRIN expression positively correlates with WHO grades of astrocytomas and meningiomas.Journal of neuro-oncology · 2013Article
- Mutation screening of mismatch repair gene Mlh3 in familial esophageal cancer.World journal of gastroenterology · 2006Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the expression of matrix metalloproteinase-9 (MMP-9) and its clinical significance in esophageal squamous cell carcinoma (ESCC).
methodsThe expression of MMP-9 in 208 cases of ESCC was detected by immunohistochemistry (IHC) and its clinical significance in ESCC especially the relationship with the clinicopathological parameters was analyzed.
resultsThe percentage of positive cases for MMP-9 detected by IHC was 49.0%. MMP-9 was mainly expressed in the cytoplasm of cancer cells especially in the invasive front. Only weak expression was detected in the stromal cells and no expression in non-cancerous mucosa. The expression of MMP-9 was positively correlated with poorer differentiation (P = 0.001<0.01), existence of vessel permeation (P = 0.027<0.05) and lymph node metastasis (P = 0.027<0.05).
conclusionThe expression of MMP-9 correlates with the cancer cell differentiation, vessel permeation and lymph node metastasis. It may be a novel biomarker for the diagnosis and treatment of ESCC.
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