ArticleThe Journal of comparative neurology2005
Nitric oxide stimulates gamma-aminobutyric acid release and inhibits glycine release in retina.
Article in The Journal of comparative neurology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- The Healthy and Diseased Retina Seen through Neuron-Glia Interactions.International journal of molecular sciences · 2024Review
- Chemical signaling in the developing avian retina: Focus on cyclic AMP and AKT-dependent pathways.Frontiers in cell and developmental biology · 2022Review
- Tonic GABAergic inhibition, via GABAThe European journal of neuroscience · 2021Article
- Metabolomic analyses of vigabatrin (VGB)-treated mice: GABA-transaminase inhibition significantly alters amino acid profiles in murine neural and non-neural tissues.Neurochemistry international · 2019Article
- Lhx9 Is Required for the Development of Retinal Nitric Oxide-Synthesizing Amacrine Cell Subtype.Molecular neurobiology · 2018Article
- Nitric oxide promotes GABA release by activating a voltage-independent CaJournal of neurophysiology · 2017Article
- Endogenous and Synthetic Cannabinoids as Therapeutics in Retinal Disease.Neural plasticity · 2016Review
- Light-evoked S-nitrosylation in the retina.The Journal of comparative neurology · 2015Article
- Differential encoding of spatial information among retinal on cone bipolar cells.Journal of neurophysiology · 2015Article
- Nitric oxide modulates the temporal properties of the glutamate response in type 4 OFF bipolar cells.PloS one · 2014Article
- The origin of neocortical nitric oxide synthase-expressing inhibitory neurons.Frontiers in neural circuits · 2012Article
- Neurochemical architecture of the central complex related to its function in the control of grasshopper acoustic communication.PloS one · 2011Article
- Light responses and morphology of bNOS-immunoreactive neurons in the mouse retina.The Journal of comparative neurology · 2010Article
- Inhibition of nitric oxide synthase desensitizes retinal ganglion cells to light by diminishing their excitatory synaptic currents under light adaptation.Vision research · 2009Article
- Increased neuronal nitric oxide synthase activity in retinal neurons in early diabetic retinopathy.Molecular vision · 2009Article
- PKG and PKA signaling in LTP at GABAergic synapses.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2009Article
- Excitatory and anti-oscillatory actions of nitric oxide in thalamus.The Journal of physiology · 2008Article
- Article
- Modulation of inhibitory activity by nitric oxide in the thalamus.Journal of neurophysiology · 2007Article
- Expression of the gamma-aminobutyric acid (GABA) plasma membrane transporter-1 in monkey and human retina.Investigative ophthalmology & visual science · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Nitric oxide (NO) modulates the uptake and/or release of neurotransmitters through a variety of cellular mechanisms. However, the pharmacological and biochemical processes underlying these neurochemical effects of NO often remain unclear. In our study, we used immunocytochemical methods to study the effects of NO, cyclic guanosine monophosphate (cGMP), and peroxynitrite on the uptake and release of gamma-aminobutyric acid (GABA) and glycine in the turtle retina. In addition, we examined the involvement of glutamate receptors, calcium, and the GABA transporter in this GABA uptake and release. We also tested for interactions between the GABAergic and glycinergic systems. In general, we show that NO stimulated GABA release and inhibited glycine release. The NO-stimulated GABA release involved calcium-dependent or calcium-independent synaptic release or reversal of the GABA transporter. Some effects of NO on GABA release involved glutamate, cGMP, or peroxynitrite. NO promoted glycine uptake and inhibited its release, and this inhibition of glycine release was influenced by GABAergic modulation. These findings indicate that NO modulates the levels of the inhibitory transmitters GABA and glycine through several specific biochemical mechanisms in different retinal cell types and layers. Thus it appears that some of the previously described reciprocal interactions between GABA and glycine in the retina function through specific NO signaling pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.