Evidence map›Paper›PMID 15682272›Full record

SynthesisJournal of human genetics2005

Association between the GLUT1 gene polymorphism and the risk of diabetic nephropathy: a meta-analysis.

Elias Zintzaras, Ioannis Stefanidis

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  5. The role of MTHFR gene in multiple myeloma.Journal of human genetics · 2008
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  18. Need for quality improvement in renal systematic reviews.Clinical journal of the American Society of Nephrology : CJASN · 2008
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Elias ZintzarasDepartment of Biomathematics, University of Thessaly School of Medicine, Papakyriazy 22, Larissa, 41222, Greece. zintza@med.uth.gr.
Ioannis StefanidisDivision of Nephrology, University Hospital of Larissa, University of Thessaly School of Medicine, Papakyriazy 22, Larissa, 41222, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The association between diabetic nephropathy (DN) and the XbalphaI polymorphism in the GLUT1 gene has been investigated in several case-control studies. These studies rendered contradictory results: the allele XbalphaI(-) was shown either to be a risk factor or neutral, or even protective for the development of the disease. To shed some light on these inconclusive findings, a meta-analysis of all available studies relating the XbalphaI polymorphism to the risk of developing DN was conducted. Five out of six identified studies included Caucasian populations, and only one involved samples from an Asian population. Overall, the meta-analysis suggested large heterogeneity between studies (P<0.01, I2=68%) and lack of association between allele XbalphaI(-) and the risk of developing DN relative to allele XbalphaI(+): random effects odds ratio (OR)=1.26 [95% CI (0.93, 1.69)]. Excluding one study with the controls not in Hardy-Weinberg equilibrium, the sensitivity analysis revealed that heterogeneity (P=0.28, I2=21%) could be explained, and then, there is an overall association: fixed effects OR=1.34 [95% CI (1.13, 1.60)]. Then, significant ORs were also found on analysis of subgroups: for the Caucasian population, fixed effects OR=1.29 [95% CI (1.08, 1.56)] and for the type 2 diabetic patients fixed effects OR=1.69 [95% CI (1.09, 2.63)]. In type 1 diabetes, there is a moderate heterogeneity (P=0.19, I2=41%) with fixed effects OR=1.29 [95% CI (1.06, 1.56)] and random effects OR=1.32 [95% CI (1.01, 1.71)]. There is a source of bias in the selected studies: large studies failed to show association while small studies claimed an association. Although there is evidence of association between GLUT1 and DN, the above findings reinforce the need for further and more rigorous association studies.

Indexed as

Polymorphism, GeneticDiabetic NephropathiesGlucose Transporter Type 1HumansMonosaccharide Transport ProteinsRisk FactorsGlucose Transporter Type 1Monosaccharide Transport ProteinsSLC2A1 protein, human

Identifiers

PMID15682272

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.