ArticleBiophysical journal2005
Maximum likelihood estimation of ion channel kinetics from macroscopic currents.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed.
- Bayesian inference of functional asymmetry in the homotrimeric ligand-gated ion channel P2XCommunications biology · 2025Article
- Using Bayesian priors to overcome non-identifiablility issues in Hidden Markov models.bioRxiv : the preprint server for biology · 2025Article
- Parameter inference for stochastic reaction models of ion channel gating from whole-cell voltage-clamp data.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Article
- Microscopic mechanism of PIEZO1 activation by pressure-induced membrane stretch.The Journal of general physiology · 2023Article
- Yoda1's energetic footprint on Piezo1 channels and its modulation by voltage and temperature.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Identification of structures for ion channel kinetic models.PLoS computational biology · 2021Article
- Calibration of ionic and cellular cardiac electrophysiology models.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Modeling the Interactions Between Sodium Channels Provides Insight Into the Negative Dominance of Certain Channel Mutations.Frontiers in physiology · 2020Article
- Slowing of the Time Course of Acidification Decreases the Acid-Sensing Ion Channel 1a Current Amplitude and Modulates Action Potential Firing in Neurons.Frontiers in cellular neuroscience · 2020Article
- Four Ways to Fit an Ion Channel Model.Biophysical journal · 2019Article
- Phenomenological models of NaScientific reports · 2019Article
- Reproducible model development in the cardiac electrophysiology Web Lab.Progress in biophysics and molecular biology · 2018Article
- OpenWorm: overview and recent advances in integrative biological simulation ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- TraceSpecks: A Software for Automated Idealization of Noisy Patch-Clamp and Imaging Data.Biophysical journal · 2018Article
- Estimating kinetic mechanisms with prior knowledge I: Linear parameter constraints.The Journal of general physiology · 2018Article
- Estimating kinetic mechanisms with prior knowledge II: Behavioral constraints and numerical tests.The Journal of general physiology · 2018Article
- Functional analyses of heteromeric human PIEZO1 Channels.PloS one · 2018Article
- Voltage-Gated Sodium Channels in Neocortical Pyramidal Neurons Display Cole-Moore Activation Kinetics.Frontiers in cellular neuroscience · 2018Article
- Identifiability, reducibility, and adaptability in allosteric macromolecules.The Journal of general physiology · 2017Article
16 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
We describe a maximum likelihood method for direct estimation of rate constants from macroscopic ion channel data for kinetic models of arbitrary size and topology. The number of channels in the preparation, and the mean and standard deviation of the unitary current can be estimated, and a priori constraints can be imposed on rate constants. The method allows for arbitrary stimulation protocols, including stimuli with finite rise time, trains of ligand or voltage steps, and global fitting across different experimental conditions. The initial state occupancies can be optimized from the fit kinetics. Utilizing arbitrary stimulation protocols and using the mean and the variance of the current reduce or eliminate problems of model identifiability (Kienker, 1989). The algorithm is faster than a recent method that uses the full autocovariance matrix (Celentano and Hawkes, 2004), in part due to the analytical calculation of the likelihood gradients. We tested the method with simulated data and with real macroscopic currents from acetylcholine receptors, elicited in response to brief pulses of carbachol. Given appropriate stimulation protocols, our method chose a reasonable model size and topology.
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