ArticleThe Journal of molecular diagnostics : JMD2005
Facile, comprehensive, high-throughput genotyping of human genital papillomaviruses using spectrally addressable liquid bead microarrays.
Article in The Journal of molecular diagnostics : JMD, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 47 citations in OpenAlex.
- Development of a bead-based suspension array for the detection of pathogens in acute respiratory tract infections.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Development of a novel liquid bead array human papillomavirus genotyping assay (PGMY-LX) and comparison with linear array for continuity in longitudinal cohort studies.Journal of clinical microbiology · 2015Article
- DNA Microarray Characterization of Pathogens Associated with Sexually Transmitted Diseases.PloS one · 2015Article
- Comparison of Seegene Anyplex II HPV28 with the PGMY-CHUV assay for human papillomavirus genotyping.Journal of clinical microbiology · 2014Article
- Novel microsphere-based method for detection and typing of 46 mucosal human papillomavirus types.Journal of clinical microbiology · 2012Article
- Development of a bead-based multiplex genotyping method for diagnostic characterization of HPV infection.PloS one · 2012Article
- Peptide nucleic acid-based array for detecting and genotyping human papillomaviruses.Journal of clinical microbiology · 2009Article
- Development and evaluation of a liquid bead microarray assay for genotyping genital human papillomaviruses.Journal of clinical microbiology · 2009Article
- Polymerase chain reaction-based fluorescent Luminex assay to detect the presence of human papillomavirus types.Cancer science · 2007Article
- Multiplexed and microparticle-based analyses: quantitative tools for the large-scale analysis of biological systems.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2006Review
- Bead-based multiplex genotyping of human papillomaviruses.Journal of clinical microbiology · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human papillomavirus (HPV) is the worldwide cause of carcinoma of the uterine cervix, a cancer that is the second most common neoplasm in women, resulting in nearly 250,000 deaths a year. The magnitude of the risk of cancer after HPV infection, however, is virus type-specific. Over 40 HPV types can infect the genital tract. Comprehensive, high-throughput typing assays for HPV, however, are not currently available. Blending multiplex PCR and multiplex hybridization using spectrally addressable liquid bead microarrays we have developed a high-throughput, fast, single-tube-typing assay capable of simultaneously typing 45 HPV. The overall incidence of HPV in 429 women tested using this new assay was 72.2% for those with squamous intraepithelial lesions, 51.5% for those with atypical squamous cells of undetermined significance and 15.4% for women with normal cytology, respectively. This compared well with the incidence of HPV detected by a parallel non-typing generic high-risk assay. The new assay detected a wide spectrum of HPV types and a high incidence of mixed infections. We believe our assay may find widespread applications in areas requiring virus type-specific information, such as in epidemiological studies, cancer screening programs, monitoring therapeutic interventions, and evaluating the efficacy of HPV vaccine trials.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.