ArticleThe Journal of molecular diagnostics : JMD2005
Kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8-positive solid lymphomas: a tissue-based variant of primary effusion lymphoma.
Article in The Journal of molecular diagnostics : JMD, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 154 citations in OpenAlex.
- An Unusual Case of Extracavitary/Solid Variant Primary Effusion Lymphoma With Associated Hemophagocytic Lymphohistiocytosis.Journal of medical cases · 2025Article
- Extracavitary primary effusion lymphoma presenting as a solitary brain mass.CNS oncology · 2024Article
- Development of a novel cell line-derived xenograft model of primary herpesvirus 8-unrelated effusion large B-cell lymphoma and antitumor activity of birabresib in vitro and in vivo.Cancer medicine · 2021Article
- Primary Effusion Lymphoma: Small Bowel Recurrence After Stem Cell Transplant.ACG case reports journal · 2021Article
- Proteomic approaches to investigate gammaherpesvirus biology and associated tumorigenesis.Advances in virus research · 2021Review
- Extracavitary primary effusion lymphoma recurring with syphilis in an HIV-infected patient.BMJ case reports · 2020Article
- The broad and challenging landscape of extranodal lymphoproliferations.Virchows Archiv : an international journal of pathology · 2020Review
- Brentuximab vedotin as frontline treatment for HIV-related extracavitary primary effusion lymphoma.International journal of hematology · 2019Article
- Activity of brentuximab vedotin in AIDS-related primary effusion lymphoma.Blood advances · 2019Article
- Primary Effusion Lymphoma without an Effusion: A Rare Case of Solid Extracavitary Variant of Primary Effusion Lymphoma in an HIV-Positive Patient.Case reports in hematology · 2018Article
- Human Herpesvirus Type 8-associated Large B-cell Lymphoma: A Nonserous Extracavitary Variant of Primary Effusion Lymphoma in an HIV-infected Man: A Case Report and Review of the Literature.Clinical lymphoma, myeloma & leukemia · 2016Review
- A KSHV microRNA enhances viral latency and induces angiogenesis by targeting GRK2 to activate the CXCR2/AKT pathway.Oncotarget · 2016Article
- Targeting HGF/c-MET induces cell cycle arrest, DNA damage, and apoptosis for primary effusion lymphoma.Blood · 2015Article
- Bub1 in Complex with LANA Recruits PCNA To Regulate Kaposi's Sarcoma-Associated Herpesvirus Latent Replication and DNA Translesion Synthesis.Journal of virology · 2015Article
- Review
- Primary effusion lymphoma presenting as a cutaneous intravascular lymphoma.Journal of cutaneous pathology · 2014Article
- Diagnosis and management of lymphomas and other cancers in HIV-infected patients.Nature reviews. Clinical oncology · 2014Review
- HHV-8-positive and EBV-positive intravascular lymphoma: an unusual presentation of extracavitary primary effusion lymphoma.The American journal of surgical pathology · 2014Article
- KSHV: pathways to tumorigenesis and persistent infection.Advances in virus research · 2014Review
- Systematic analysis of a xenograft mice model for KSHV+ primary effusion lymphoma (PEL).PloS one · 2014Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV), also termed human herpesvirus type 8, is consistently identified in Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease. Here we report four cases of KSHV-bearing solid lymphomas that occurred in AIDS patients (cases 1 to 3) and in a human immunodeficiency virus (HIV)-seronegative person (case 4). The patients presented extranodal masses in the abdomen (cases 1, 3, and 4) or skin (case 2), and nodal involvement, together with Kaposi's sarcoma (case 3). The gastrointestinal tract was involved in two patients (cases 1 and 3). The patients did not develop a lymphomatous effusion. KSHV was detected in the tumor cells of all cases by immunohistochemistry and by polymerase chain reaction. Epstein-Barr virus was detected in two of the HIV-related cases. All KSHV-positive solid lymphomas exhibited PEL-like cell morphology. To investigate the relationship of these disorders to PEL and to other AIDS-associated diffuse large cell lymphomas, KSHV-positive solid lymphomas were tested for the expression of a set of genes that were previously shown by gene profiling analysis to define PEL tumor cells. The results showed that expression of this set of genes in KSHV-positive lymphomas is similar to that of PEL but distinct from KSHV-negative AIDS-associated diffuse large cell lymphomas. Because pathobiological features of KSHV-positive solid lymphomas closely mimic those of PEL, our results suggest that KSHV-positive solid lymphomas should be considered as a tissue-based variant of classical PEL, irrespective of HIV status.
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