ArticleJournal of virology2005
The proline-rich homeodomain (PRH/HEX) protein is down-regulated in liver during infection with lymphocytic choriomeningitis virus.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
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- Molecular determinants of arenavirus Z protein homo-oligomerization and L polymerase binding.Journal of virology · 2011Article
- Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever.Antiviral research · 2011Review
- Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- An antiviral disulfide compound blocks interaction between arenavirus Z protein and cellular promyelocytic leukemia protein.Biochemical and biophysical research communications · 2010Article
- Z proteins of New World arenaviruses bind RIG-I and interfere with type I interferon induction.Journal of virology · 2010Article
- Inhibition of Junín virus replication by small interfering RNAs.Antiviral research · 2009Article
- Gene expression in primate liver during viral hemorrhagic fever.Virology journal · 2009Article
- PRH/Hex: an oligomeric transcription factor and multifunctional regulator of cell fate.The Biochemical journal · 2008Review
- Early blood profiles of virus infection in a monkey model for Lassa fever.Journal of virology · 2007Article
- Arenavirus Z protein as an antiviral target: virus inactivation and protein oligomerization by zinc finger-reactive compounds.The Journal of general virology · 2006Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
The proline-rich homeodomain protein, PRH/HEX, participates in the early development of the brain, thyroid, and liver and in the later regenerative processes of damaged liver, vascular endothelial, and hematopoietic cells. A virulent strain of lymphocytic choriomeningitis virus (LCMV-WE) that destroys hematopoietic, vascular, and liver functions also alters the transcription and subcellular localization of PRH. A related virus (LCMV-ARM) that does not cause disease in primates can infect cells without affecting PRH. Biochemical experiments demonstrated the occurrence of binding between the viral RING protein (Z) and PRH, and genetic experiments mapped the PRH-suppressing phenotype to the large (L) segment of the viral genome, which encodes the Z and polymerase genes. The Z protein is clearly involved with PRH, but other viral determinants are needed to relocate PRH and to promote disease. By down-regulating PRH, the arenavirus is able to eliminate the antiproliferative effects of PRH and to promote liver cell division. The interaction of an arenavirus with a homeodomain protein suggests a mechanism for viral teratogenic effects and for the tissue-specific manifestations of arenavirus disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.