ArticleJournal of virology2005
Identification of specific cellular genes up-regulated late in adenovirus type 12 infection.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Extracellular matrix protein CCN1 limits oncolytic efficacy in glioma.Cancer research · 2012Article
- The ISG56/IFIT1 gene family.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2011Review
- High-throughput sequencing of microRNAs in adenovirus type 3 infected human laryngeal epithelial cells.Journal of biomedicine & biotechnology · 2010Article
- Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation.BMC genomics · 2009Article
- Induction of neuronal and tumor-related genes by adenovirus type 12 E1A.Journal of virology · 2009Article
- A quantitative proteomic approach for identification of potential biomarkers in hepatocellular carcinoma.Journal of proteome research · 2008Article
- Oncolytic HSV-1 infection of tumors induces angiogenesis and upregulates CYR61.Molecular therapy : the journal of the American Society of Gene Therapy · 2008Article
- Suppression of interferon (IFN)-inducible genes and IFN-mediated functional responses in BCR-ABL-expressing cells.The Journal of biological chemistry · 2008Article
- Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications.Virus research · 2008Review
- Functional analysis of the transcription repressor PLU-1/JARID1B.Molecular and cellular biology · 2007Article
- The cellular response to herpes simplex virus type 1 (HSV-1) during latency and reactivation.Journal of neurovirology · 2005Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The infection of human cells by adenoviruses leads to a gradual reduction in the activity of host cell functions while viral gene expression progresses in a regulated way. We used the DNA microarray technique to determine the transcriptional activity profiles of cellular genes upon infection with adenovirus type 12 (Ad12). The microarray data were validated by quantitative real-time PCR for genes which showed significant alterations after Ad12 infection. At 12 h postinfection, there is a striking up-regulation between 10- and 30-fold in the expression of the G1P2, IFIT1, and IFIT2 cellular immune response genes compared to mock-infected cells. At later stages of infection, when the majority of regulated cellular genes has been turned down, a limited number of cellular genes exhibit increased activities by factors of 3 or less. These genes belong to the signal transduction or transcriptional regulator classes or are active in protein degradation, like ANPEP, an aminopeptidase. The SCD and CYP2S1 genes function in lipid metabolism. The eucaryotic translation initiation factor 4 is up-regulated, and one of the major histocompatibility complex genes is diminished in activity. For two of the genes, one up-regulated (CTSF gene) and one down-regulated (CYR61 gene), alterations in gene activity were confirmed at the protein level by Western blotting experiments. Increased genetic activity of cellular genes late in adenovirus infection has not been reported previously and demonstrates that Ad12 has a sustained control of host cell gene expression well into the late phase of infection.
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