ArticleJournal of anatomy2005
Quantification of N-CAM and N-cadherin expression in axotomized and crushed rat sciatic nerve.
Article in Journal of anatomy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Endogenous Network Modeling Reveals Mechanisms of Repair Schwann Cell Decline and Potential Recovery Targets.Biology · 2026Article
- Beyond conventional therapies: MSCs in the battle against nerve injury.Regenerative therapy · 2025Review
- Nature's Secret Neuro-Regeneration Pathway in Axolotls, Polychaetes and Planarians for Human Therapeutic Target Pathways.International journal of molecular sciences · 2024Review
- A Review on the Role of Endogenous Neurotrophins and Schwann Cells in Axonal Regeneration.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2022Review
- Chitosan Micro-Grooved Membranes with Increased Asymmetry for the Improvement of the Schwann Cell Response in Nerve Regeneration.International journal of molecular sciences · 2021Article
- Review
- The transcriptome of anterior regeneration in earthworm Eudrilus eugeniae.Molecular biology reports · 2021Article
- p75 and neural cell adhesion molecule 1 can identify pathologic Schwann cells in peripheral neuropathies.Annals of clinical and translational neurology · 2019Article
- N-Cadherin is Involved in Neuronal Activity-Dependent Regulation of Myelinating Capacity of Zebrafish Individual Oligodendrocytes In Vivo.Molecular neurobiology · 2017Article
- Transcriptome Analysis on Monocytes from Patients with Neovascular Age-Related Macular Degeneration.Scientific reports · 2016Article
- Nerve demyelination increases metabotropic glutamate receptor subtype 5 expression in peripheral painful mononeuropathy.International journal of molecular sciences · 2015Article
- Axonal regeneration in early stages of sciatic nerve crush injury is enhanced by α7nAChR in rats.Molecular biology reports · 2015Article
- Reproducible mouse sciatic nerve crush and subsequent assessment of regeneration by whole mount muscle analysis.Journal of visualized experiments : JoVE · 2012Article
- Spatiotemporal expression profiling of proteins in rat sciatic nerve regeneration using reverse phase protein arrays.Proteome science · 2012Article
- Extrinsic and intrinsic determinants of nerve regeneration.Journal of tissue engineering · 2011Article
- Diffusion tensor imaging of cocaine-treated rodents.Psychiatry research · 2009Article
- Article
- Spatiotemporal expression of PSD-95 and nNOS after rat sciatic nerve injury.Neurochemical research · 2008Article
- Expression and localization of the cell adhesion molecule SgIGSF during regeneration of the olfactory epithelium in mice.Acta histochemica et cytochemica · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Adhesion molecules are important in supporting axonal regeneration. Qualitative studies have described increased expression of neural cell adhesion molecule (NCAM) and N-cadherin in models of nerve injury allowing active regeneration. In this study we have used quantitative immunohistochemistry to compare expression of NCAM and N-cadherin after nerve injury either with active regeneration (crush) into the distal stump or without (axotomy and capping). Quantification was performed 15 days after axotomy in proximal and distal stumps. Quantification after crush either proximal, distal or within the crushed area was performed at 2, 7, 15 and 30 days after injury. Axotomy induced increases in expression in proximal stumps between two and three times those in uninjured nerves for both molecules. In distal stumps, N-cadherin levels increased seven-fold, yet NCAM levels did not exceed control values. After crush, NCAM immunoreactivity increased in the crushed area and distal stump in contrast to axotomy and NCAM-positive axons co-localized with PGP9.5. N-cadherin levels in the distal stump increased above control levels, but the magnitude of the increase seen after crush was different to those seen after axotomy. In conclusion, increased expression of adhesion molecules, particularly NCAM, in the distal stump of injured nerves is dependent upon the presence of regenerating axons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.