ArticleClinical & experimental metastasis2004
Common origins of MDA-MB-435 cells from various sources with those shown to have melanoma properties.
Article in Clinical & experimental metastasis, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 74 citations in OpenAlex.
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- Minocycline impairs TNF-α-induced cell fusion of M13SV1-Cre cells with MDA-MB-435-pFDR1 cells by suppressing NF-κB transcriptional activity and its induction of target-gene expression of fusion-relevant factors.Cell communication and signaling : CCS · 2019Article
- Authentication of M14 melanoma cell line proves misidentification of MDA-MB-435 breast cancer cell line.International journal of cancer · 2018Article
- Silencing of TGF-β1 in tumor cells impacts MMP-9 in tumor microenvironment.Scientific reports · 2017Article
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- In Vivo Electrical Conductivity Contrast Imaging in a Mouse Model of Cancer Using High-Frequency Magnetoacoustic Tomography With Magnetic Induction (hfMAT-MI).IEEE transactions on medical imaging · 2016Article
- Prior knowledge transfer across transcriptional data sets and technologies using compositional statistics yields new mislabelled ovarian cell line.Nucleic acids research · 2016Article
- Probe for the measurement of cell surface pH in vivo and ex vivo.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- CXCL12 retargeting of an adenovirus vector to cancer cells using a bispecific adapter.Oncolytic virotherapy · 2016Article
- Continued use of MDA-MB-435, a melanoma cell line, as a model for human breast cancer, even in year, 2014.NPJ breast cancer · 2015Article
- Density-dependent lineage instability of MDA-MB-435 breast cancer cells.Oncology letters · 2013Article
- Differential secretome analysis reveals CST6 as a suppressor of breast cancer bone metastasis.Cell research · 2012Article
- Thyroid cancer cell lines: Critical models to study thyroid cancer biology and new therapeutic targets.Frontiers in endocrinology · 2012Article
- TWIST represses estrogen receptor-alpha expression by recruiting the NuRD protein complex in breast cancer cells.International journal of biological sciences · 2012Article
- Choosing the right cell line for breast cancer research.Breast cancer research : BCR · 2011Review
- A role for nucleotides in support of breast cancer angiogenesis: heterologous receptor signalling.British journal of cancer · 2011Article
- In vitro and in vivo evaluation of ⁶⁴Cu-radiolabeled KCCYSL peptides for targeting epidermal growth factor receptor-2 in breast carcinomas.Cancer biotherapy & radiopharmaceuticals · 2010Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Recently, the tissue origin of MDA-MB-435 cell line has been the subject of considerable debate. In this study, we set out to determine whether MDA-MB-435-DTP cells shown to express melanoma-specific genes were identical to various other MDA-MB-435 cell stocks worldwide. CGH-microarray, genetic polymorphism genotyping, microsatellite fingerprint analysis and/or chromosomal number confirmed that the MDA-MB-435 cells maintained at the Lombardi Comprehensive Cancer Center (MDA-MB-435-LCC) are almost identical to the MDA-MB-435-DTP cells, and showed a very similar profile to those obtained from the same original source (MD Anderson Cancer Center) but maintained independently (MDA-MB-435-PMCC). Gene expression profile analysis confirmed common expression of genes among different MDA-MB-435-LCC cell stocks, and identified some unique gene products in MDA-MB-435-PMCC cells. RT-PCR analysis confirmed the expression of the melanoma marker tyrosinase across multiple MDA-MB-435 cell stocks. Collectively, our results show that the MDA-MB-435 cells used widely have identical origins to those that exhibit a melanoma-like gene expression signature, but exhibit a small degree of genotypic and phenotypic drift.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.