ArticleThe Journal of comparative neurology2005
Effects of functional group position on spatial representations of aliphatic odorants in the rat olfactory bulb.
Article in The Journal of comparative neurology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Structural spine plasticity: Learning and forgetting of odor-specific subnetworks in the olfactory bulb.PLoS computational biology · 2022Article
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- Space Takes Time: Concentration Dependent Output Codes from Primary Olfactory Networks Rapidly Provide Additional Information at Defined Discrimination Thresholds.Frontiers in cellular neuroscience · 2015Article
- Article
- Dynamic sensory representations in the olfactory bulb: modulation by wakefulness and experience.Neuron · 2012Article
- Detailed Characterization of Local Field Potential Oscillations and Their Relationship to Spike Timing in the Antennal Lobe of the Moth Manduca sexta.Frontiers in neuroengineering · 2011Article
- Olfactory discrimination varies in mice with different levels of α7-nicotinic acetylcholine receptor expression.Brain research · 2010Article
- Spatial representations of odorants in olfactory bulbs of rats and mice: similarities and differences in chemotopic organization.The Journal of comparative neurology · 2009Article
- Processing and classification of chemical data inspired by insect olfaction.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Olfactory discrimination ability of CD-1 mice for aliphatic aldehydes as a function of stimulus concentration.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2007Article
- Chemotopic odorant coding in a mammalian olfactory system.The Journal of comparative neurology · 2007Review
- Odorants with multiple oxygen-containing functional groups and other odorants with high water solubility preferentially activate posterior olfactory bulb glomeruli.The Journal of comparative neurology · 2007Article
- SenseLab: new developments in disseminating neuroscience information.Briefings in bioinformatics · 2007Article
- Effects of double and triple bonds on the spatial representations of odorants in the rat olfactory bulb.The Journal of comparative neurology · 2007Article
- OdorMapComparer: an application for quantitative analyses and comparisons of fMRI brain odor maps.Neuroinformatics · 2007Article
- Differential responses to branched and unsaturated aliphatic hydrocarbons in the rat olfactory system.The Journal of comparative neurology · 2006Article
- Predicting odorant quality perceptions from multidimensional scaling of olfactory bulb glomerular activity patterns.Behavioral neuroscience · 2006Article
- Differential specificity in the glomerular response profiles for alicyclic, bicyclic, and heterocyclic odorants.The Journal of comparative neurology · 2006Article
- Long hydrocarbon chains serve as unique molecular features recognized by ventral glomeruli of the rat olfactory bulb.The Journal of comparative neurology · 2006Article
- Sparse odor coding in awake behaving mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Principles of olfactory coding can be clarified by studying the olfactory bulb activity patterns that are evoked by odorants differing systematically in chemical structure. In the present study, we used series of aliphatic esters, ketones, and alcohols (27 odorants total) to determine the effects of functional group position on glomerular-layer activity patterns. These patterns were measured as uptake of [(14)C]2-deoxyglucose and were mapped into standardized data matrices for statistical comparison across different rats. The magnitude of the effect of position differed greatly for the different functional groups. For ketones, there was little or no effect of position on evoked patterns. For esters, uptake in individual glomerular modules increased, whereas uptake in others decreased with changing group position, yet the overall patterns remained similar. For alcohols, group position had a profound effect on evoked activity patterns. For example, moving the hydroxyl group in either heptanol or nonanol from the first to the fourth carbon changed the activity patterns so greatly that the major areas of response did not overlap. Within every functional group series, however, responses were globally chemotopic, such that pairs of odorants with the smallest difference in functional group position evoked the most similar patterns. These results help to define further the specificities of glomeruli within previously described glomerular modules, and they show that functional group position can be an important feature in encoding an odorant molecule.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.