ArticleIntensive care medicine2005
Identifying infants at risk of marked thyroid suppression post-cardiopulmonary bypass.
Article in Intensive care medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06660823 (Role of Levothyroxine Supplementation in Delayed Recovery Following Cardiac Surgery), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Levothyroxine Supplementation in Delayed Recovery Following Cardiac Surgery
Who cites it
12 citing papers in PubMed.
- Trial
- Trial
- Effect of perioperative use of oral triidothyronine for infants undergoing complex congenital cardiac surgeries under cardiopulmonary bypass: A double-blinded randomised controlled study.Annals of cardiac anaesthesiaTrial
- Trisomy 21 and Congenital Heart Disease: Impact on Health and Functional Outcomes From Birth Through Adolescence: A Scientific Statement From the American Heart Association.Journal of the American Heart Association · 2024Review
- Relationship between preoperative FT3 levels and new-onset atrial fibrillation after off-pump coronary artery bypass grafting.Journal of thoracic disease · 2024Article
- Predictors of Low Cardiac Output Syndrome in Infants After Open-Heart Surgery.Frontiers in pediatrics · 2022Article
- The Current Status of Neuroprotection in Congenital Heart Disease.Children (Basel, Switzerland) · 2021Review
- Non-thyroidal illness syndrome and cardiopulmonary bypass in children with congenital heart disease.Caspian journal of internal medicine · 2014Article
- Thyroid hormone and cortisol concentrations after congenital heart surgery in infants younger than 3 months of age.Intensive care medicine · 2010Article
- Nonthyroidal illness syndrome in children.Endocrine · 2009Review
- Year in review in intensive care medicine, 2005. III. Nutrition, pediatric and neonatal critical care, and experimental.Intensive care medicine · 2006Review
- Clinical review: thyroid hormone replacement in children after cardiac surgery--is it worth a try?Critical care (London, England) · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe clinical benefit of tri-iodothyrinone (T(3)) replacement following congenital heart surgery with cardiopulmonary bypass (CPB) is not clear in unselected cohorts of children. Infants with more marked thyroid hormone suppression or prolonged post-CPB recovery may benefit from T(3) replacement. This study aimed to identify infants at risk of more marked suppression by examining the relationship between organ support parameters during CPB and post-operative thyroid hormone levels. DESIGN AND
settingProspective observational study in a tertiary referral centre for congenital heart surgery. PATIENTS: 36 infants less than 12 months of age were recruited following CPB. MEASUREMENTS AND
resultsThyroid hormone levels were measured on admission to the intensive care unit and on post-operative days 1 and 2. Increasing CPB time was associated with decreasing admission free T(3) and thyroid-stimulating hormone. Younger, smaller infants had lower admission levels of free T(3) on univariant analysis. Infants who continued to require ventilation 48 h after admission to the ICU had a mean free T(3) level on post-operative day 2 that was 0.9 pmol/l lower than in those who had been extubated.
conclusionsProspective studies of T(3) replacement in selected young infants (less than 3 months) with long CPB time (greater than 120 min) during congenital heart surgery are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.