ArticleGenetics2005
Predictions of patterns of response to artificial selection in lines derived from natural populations.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Natural dispersal is better than translocation for reducing risks of inbreeding depression in eastern black rhinoceros (Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Prediction of additive genetic variances of descendants for complex families based on Mendelian sampling variances.G3 (Bethesda, Md.) · 2024Article
- Quantifying resistance to myxomatosis in wild rabbits produces novel evolutionary insights.Epidemiology and infection · 2023Article
- Article
- The genetic architecture of temperature adaptation is shaped by population ancestry and not by selection regime.Genome biology · 2021Article
- Article
- Influence of epistasis on response to genomic selection using complete sequence data.Genetics, selection, evolution : GSE · 2017Article
- Increased genetic gains in sheep, beef and dairy breeding programs from using female reproductive technologies combined with optimal contribution selection and genomic breeding values.Genetics, selection, evolution : GSE · 2015Article
- Dearth of polymorphism associated with a sustained response to selection for flowering time in maize.BMC evolutionary biology · 2015Article
- Development of a Nasonia vitripennis outbred laboratory population for genetic analysis.Molecular ecology resources · 2014Article
- Applications of population genetics to animal breeding, from wright, fisher and lush to genomic prediction.Genetics · 2014Review
- Quantitative genetics in the genomics era.Current genomics · 2012Article
- Dynamics of long-term genomic selection.Genetics, selection, evolution : GSE · 2010Article
- Common SNPs explain a large proportion of the heritability for human height.Nature genetics · 2010Article
- Understanding and using quantitative genetic variation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Article
- Additive genetic variability and the Bayesian alphabet.Genetics · 2009Review
- Article
- Data and theory point to mainly additive genetic variance for complex traits.PLoS genetics · 2008Review
- Article
- Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles.Human heredity · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pattern of response to artificial selection on quantitative traits in laboratory populations can tell us something of the genetic architecture in the natural population from which they were derived. We modeled artificial selection in samples drawn from natural populations in which variation had been maintained by recurrent mutation, with genes having an effect on the trait, which was subject to real stabilizing selection, and a pleitropic effect on fitness (the joint-effect model). Natural selection leads to an inverse correlation between effects and frequencies of genes, such that the frequency distribution of genes increasing the trait has an extreme U-shape. In contrast to the classical infinitesimal model, an early accelerated response and a larger variance of response among replicates were predicted. However, these are reduced if the base population has been maintained in the laboratory for some generations by random sampling prior to artificial selection. When multiple loci and linkage are also taken into account, the gametic disequilibria generated by the Bulmer and Hill-Robertson effects are such that little or no increase in variance and acceleration of response in early generations of artificial selection are predicted; further, the patterns of predicted responses for the joint-effect model now become close to those of the infinitesimal model. Comparison with data from laboratory selection experiments shows that, overall, the analysis did not provide clear support for the joint-effect model or a clear case for rejection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.