ArticleThe Journal of physiology2005
Fast erg K+ currents in rat embryonic serotonergic neurones.
Article in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Purkinje cell hyperexcitability and depressive-like behavior in mice lacking erg3 (ether-à-go-go-related gene) KScience advances · 2024Article
- Kv11 (ether-à-go-go-related gene) voltage-dependent KThe Journal of physiology · 2021Article
- ERG Channels Regulate Excitability in Stellate and Bushy Cells of Mice Ventral Cochlear Nucleus.The Journal of membrane biology · 2018Article
- Ether-à-go-go KThe Journal of physiology · 2018Review
- Inverse Modulation of Neuronal KFrontiers in molecular neuroscience · 2018Article
- Effects of Temperature on Heteromeric Kv11.1a/1b and Kv11.3 Channels.Biophysical journal · 2016Article
- Ether-à-go-go family voltage-gated K+ channels evolved in an ancestral metazoan and functionally diversified in a cnidarian-bilaterian ancestor.The Journal of experimental biology · 2015Article
- Erg potassium currents of neonatal mouse Purkinje cells exhibit fast gating kinetics and are inhibited by mGluR1 activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Inhibition of HERG1 K+ channel protein expression decreases cell proliferation of human small cell lung cancer cells.Pflugers Archiv : European journal of physiology · 2012Article
- Role of ERG1 isoforms in modulation of ERG1 channel trafficking and function.Pflugers Archiv : European journal of physiology · 2010Review
- HERG1 channelopathies.Pflugers Archiv : European journal of physiology · 2010Review
- Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study.Behavioral and brain functions : BBF · 2010Article
- Expression and immunolocalization of ERG1 potassium channels in the rat kidney.Histochemistry and cell biology · 2010Article
- Erg K+ currents modulate excitability in mouse mitral/tufted neurons.Pflugers Archiv : European journal of physiology · 2009Article
- Ether-à-gogo-related gene (erg1) potassium channels shape the dark response of horizontal cells in the mammalian retina.Pflugers Archiv : European journal of physiology · 2009Article
- Homeostatic control of sensory output in basal vomeronasal neurons: activity-dependent expression of ether-à-go-go-related gene potassium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current.Pflugers Archiv : European journal of physiology · 2008Article
- Two novel ergtoxins, blockers of K+-channels, purified from the Mexican scorpion Centruroides elegans elegans.Neurochemical research · 2008Article
- ERG conductance expression modulates the excitability of ventral horn GABAergic interneurons that control rhythmic oscillations in the developing mouse spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Effects of TRH on heteromeric rat erg1a/1b K+ channels are dominated by the rerg1b subunit.The Journal of physiology · 2006Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ether-á-go-go-related gene (erg) channels form one subfamily of the ether-á-go-go (EAG) K(+) channels and all three erg channels (erg1-3) are expressed in the brain. In the present study we characterize a fast erg current in neurones in primary culture derived from the median part of rat embryonic rhombencephala (E15-16). The relatively uniform erg current was regularly found in large multipolar serotonergic neurones, and occurred also in other less well characterized neurones. The erg current was blocked by the antiarrhythmic substance E-4031. Single-cell RT-PCR revealed the expression of erg1a, erg1b, erg2 and erg3 mRNA in different combinations in large multipolar neurones. These cells also contained neuronal tryptophan hydroxylase, a key enzyme for serotonin production. To characterize the molecular properties of the channels mediating the native erg current, we compared the voltage and time dependence of activation and deactivation of the neuronal erg current to erg1a, erg1b, erg2 and erg3 currents heterologously expressed in CHO cells. The biophysical properties of the neuronal erg current were well within the range displayed by the different heterologously expressed erg currents. Activation and deactivation kinetics of the neuronal erg current were fast and resembled those of erg3 currents. Our data suggest that the erg channels in rat embryonic rhombencephalon neurones are heteromultimers formed by different erg channel subunits.
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