ArticleBlood2005
Induction of polyploidization in leukemic cell lines and primary bone marrow by Src kinase inhibitor SU6656.
Article in Blood, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Optimizing the Method for Differentiation of Functional Platelets from Human Induced Pluripotent Stem Cells.Stem cell reviews and reports · 2026Article
- Generation and manipulation of human iPSC-derived platelets.Cellular and molecular life sciences : CMLS · 2021Review
- The (Patho)Biology of SRC Kinase in Platelets and Megakaryocytes.Medicina (Kaunas, Lithuania) · 2020Review
- Article
- Article
- Induction of differentiation of human stem cellsWorld journal of stem cells · 2019Review
- Drug-induced aneuploidy and polyploidy is a mechanism of disease relapse in MYC/BCL2-addicted diffuse large B-cell lymphoma.Oncotarget · 2018Article
- Enhancing functional platelet release in vivo from in vitro-grown megakaryocytes using small molecule inhibitors.Blood advances · 2018Article
- Recent developments in ex vivo platelet production.Cytotechnology · 2016Review
- Transient endoreplication down-regulates the kinesin-14 HSET and contributes to genomic instability.Molecular biology of the cell · 2016Article
- BMS-777607 promotes megakaryocytic differentiation and induces polyploidization in the CHRF-288-11 cells.Human cell · 2015Article
- Bone marrow pathology predicts mortality in chronic hemodialysis patients.BioMed research international · 2015Observational
- Molecular pathways: induction of polyploidy as a novel differentiation therapy for leukemia.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Article
- Review
- Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.Cell · 2012Article
- A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation.Genes & development · 2012Article
- Distinct functional effects for dynamin 3 during megakaryocytopoiesis.Stem cells and development · 2011Article
- Article
- An image-based, high-throughput screening assay for molecules that induce excess DNA replication in human cancer cells.Molecular cancer research : MCR · 2011Article
- In vitro megakaryocyte production and platelet biogenesis: state of the art.Transfusion medicine reviews · 2010Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Megakaryocytes (MKs) undergo successive rounds of endomitosis during differentiation, resulting in polyploidy (typically, 16-64N). Previous studies have demonstrated that this occurs through an interruption of normal cell cycle progression during anaphase. However, the molecular mechanism(s) controlling this unique process is undefined. In the present report, we examine the effect of an Src kinase inhibitor, SU6656, on thrombopoietin (TPO)-induced growth and differentiation. Remarkably, when SU6656 (2.5 microM) was added to a megakaryocytic cell line, UT-7/TPO, the cells ceased cell division but continued to accumulate DNA by endomitosis. During this interval, CD41 and CD61 expression on the cell surface increased. Similar effects on polyploidization and MK differentiation were seen with expanded primary MKs, bone marrow from 2 patients with myelodysplastic syndrome, and other cell lines with MK potential. Our data suggest that SU6656 might be useful as a differentiation-inducing agent for MKs and is an important tool for understanding the molecular basis of MK endomitosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.