ArticleJournal of the Association for Research in Otolaryngology : JARO2004
Evidence that rapid vesicle replenishment of the synaptic ribbon mediates recovery from short-term adaptation at the hair cell afferent synapse.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 103 citations in OpenAlex.
- Article
- Inhibition of TLR4 mitigates sensorineural hearing loss resulting from cochlear inflammation.Molecular medicine (Cambridge, Mass.) · 2025Article
- Article
- CaProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Otoferlin as a multirole CaFrontiers in cellular neuroscience · 2023Review
- Estimating health of the implanted cochlea using psychophysical strength-duration functions and electrode configuration.Hearing research · 2022Article
- Sensory adaptation at ribbon synapses in the zebrafish lateral line.The Journal of physiology · 2021Article
- The Interplay Between Spike-Time and Spike-Rate Modes in the Auditory Nerve Encodes Tone-In-Noise Threshold.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Otoferlin acts as a CaeLife · 2017Article
- Mechanisms of synaptic depression at the hair cell ribbon synapse that support auditory nerve function.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Different CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- RIM-Binding Protein 2 Promotes a Large Number of CaFrontiers in cellular neuroscience · 2017Article
- Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.The EMBO journal · 2016Article
- Actin Filaments Regulate Exocytosis at the Hair Cell Ribbon Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Synaptopathy in the noise-exposed and aging cochlea: Primary neural degeneration in acquired sensorineural hearing loss.Hearing research · 2015Article
- EF-hand protein Ca2+ buffers regulate Ca2+ influx and exocytosis in sensory hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- ArfGAP3 is a component of the photoreceptor synaptic ribbon complex and forms an NAD(H)-regulated, redox-sensitive complex with RIBEYE that is important for endocytosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Quantitative analysis of ribbons, vesicles, and cisterns at the cat inner hair cell synapse: correlations with spontaneous rate.The Journal of comparative neurology · 2013Article
- Single Ca2+ channels and exocytosis at sensory synapses.The Journal of physiology · 2013Review
- A local, periactive zone endocytic machinery at photoreceptor synapses in close vicinity to synaptic ribbons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We have employed both in vitro patch clamp recordings of hair cell synaptic vesicle fusion and in vivo single unit recording of cochlear nerve activity to study, at the same synapse, the time course, control, and physiological significance of readily releasable pool dynamics. Exocytosis of the readily releasable pool was fast, saturating in less than 50 ms, and recovery was also rapid, regaining 95% of its initial amplitude following a 200-ms period of repolarization. Longer depolarizations (greater than 250 ms) yielded a second, slower kinetic component of exocytosis. Both the second component of exocytosis and recovery of the readily releasable pool were blocked by the slow calcium buffer, EGTA. Sound-evoked afferent synaptic activity adapted and recovered with similar time courses as readily releasable pool exhaustion and recovery. Comparison of readily releasable pool amplitude, capture distances of calcium buffers, and number of vesicles tethered to the synaptic ribbon suggested that readily releasable pool dynamics reflect the depletion of release-ready vesicles tethered to the synaptic ribbon and the reloading of the ribbon with vesicles from the cytoplasm. Thus, we submit that rapid recovery of the cochlear hair cell afferent fiber synapse from short-term adaptation depends on the timely replenishment of the synaptic ribbon with vesicles from a cytoplasmic pool. This apparent rapid reloading of the synaptic ribbon with vesicles underscores important functional differences between synaptic ribbons in the auditory and visual systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.