SynthesisThe Cochrane database of systematic reviews2005
Hyperbaric oxygen therapy for promoting fracture healing and treating fracture non-union.
Synthesis in The Cochrane database of systematic reviews, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Hyperbaric oxygen therapy for treating acute surgical and traumatic wounds.The Cochrane database of systematic reviews · 2013Pooled it
- Hyperbaric oxygen therapy for promoting fracture healing and treating fracture non-union.The Cochrane database of systematic reviews · 2012Pooled it
- Hyperbaric oxygen therapy: solution for difficult to heal acute wounds? Systematic review.World journal of surgery · 2011Pooled it
- Hyperbaric Oxygen for Lower Limb Trauma (HOLLT): an international multi-centre randomised clinical trial.Diving and hyperbaric medicine · 2022Trial
- When broken bones need air: Erythrocytes step in to heal.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Hyperbaric Oxygen Therapy for the Treatment of Bone-Related Diseases.International journal of molecular sciences · 2025Review
- Therapeutic Efficacy and Safety of Osteoinductive Factors and Cellular Therapies for Long Bone Fractures and Non-Unions: A Meta-Analysis and Systematic Review.Journal of clinical medicine · 2022Review
- Hyperbaric Oxygen Therapy Improves the Osteogenic and Vasculogenic Properties of Mesenchymal Stem Cells in the Presence of Inflammation In Vitro.International journal of molecular sciences · 2020Article
- Periosteal Distraction Osteogenesis: An Effective Method for Bone Regeneration.BioMed research international · 2016Review
- Effect of hyperbaric oxygen therapy combined with autologous platelet concentrate applied in rabbit fibula fraction healing.Clinics (Sao Paulo, Brazil) · 2013Article
- The role of oxygen during fracture healing.Bone · 2013Article
- Hyperbaric oxygen for osteomyelitis in a compromised host.The open orthopaedics journal · 2013Article
- Hyperbaric oxygen effects on sports injuries.Therapeutic advances in musculoskeletal disease · 2011Article
- Adjunctive therapies in the treatment of osteomyelitis.Seminars in plastic surgery · 2009Article
- Influence of adjuvant hyperbaric oxygen therapy on short-term complications during surgical reconstruction of upper and lower extremity war injuries: retrospective cohort study.Croatian medical journal · 2008Article
- Best evidence topic report. Hyperbaric oxygen therapy in acute fracture management.Emergency medicine journal : EMJ · 2006Review
- Stress fractures: definition, diagnosis and treatment.Revista brasileira de ortopediaArticle
Corrections and comments
- Retraction · 2012-03-14Notice - Limited or No Information · Removed ·
- Updated by
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyperbaric oxygen therapy (HBOT) consists of intermittently administering 100% oxygen at pressures greater than one atmosphere absolute (ATA) in a pressure vessel. This technology has been used to treat a variety of diseases and has been described as helping patients who have delayed healing or established non-union of bony fractures.
objectivesThe aim of this review was to assess the evidence for the benefit of hyperbaric oxygen treatment (HBOT) for the treatment of delayed bony healing and established non-union of bony fractures. SEARCH STRATEGY: We searched the Cochrane Musculoskeletal Injuries Group trials register (to January week 3, 2004), the Cochrane Central Register of Controlled Trials (The Cochrane Library Issue 4, 2003), MEDLINE (OVID 1966 to January week 3, 2004), CINAHL (OVID 1982 to January week 3, 2004), EMBASE (OVID 1980 to February 2004), the locally developed Database of Randomised Controlled Trials in Hyperbaric Medicine (available at www.hboevidence.com) from inception to March 2004, and reference lists of articles. SELECTION CRITERIA: We aimed to include all randomised controlled trials that compared the effect of HBOT with no HBOT (no treatment or sham). DATA COLLECTION AND ANALYSIS: Two authors using standardised forms attempted to extract data independently. MAIN
resultsNo trials met the inclusion criteria. We excluded one trial that compared HBOT with no treatment because no clinical outcomes were reported. AUTHORS'
conclusionsThis systematic review failed to locate any relevant clinical evidence to support or refute the effectiveness of HBOT for the management of delayed union or established non-union of bony fractures. Good quality clinical trials are needed to define the role, if any, of HBOT in the treatment of these injuries.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.