ArticleMammalian genome : official journal of the International Mammalian Genome Society2005
Two reciprocal translocations provide new clues to the high mutability of the Grid2 locus.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 11 citations in OpenAlex.
- A Mouse Mutation That Dysregulates NeighboringG3 (Bethesda, Md.) · 2019Article
- The human δ2 glutamate receptor gene is not mutated in patients with spinocerebellar ataxia.Neural regeneration research · 2014Article
- A new mouse allele of glutamate receptor delta 2 with cerebellar atrophy and progressive ataxia.PloS one · 2014Article
- Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing.Nature genetics · 2008Article
- Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains.Alcoholism, clinical and experimental research · 2007Article
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5 authors at 1 institution in 1 country.
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Abstract
We describe two new mutations, 153Gso and 154Gso, associated with reciprocal translocations with a common breakpoint in mouse chromosome 6B3 (Mmu6B3). The translocations arose independently in offspring of male mice treated with chlorambucil and glycidamide, respectively. Homozygotes of both mutant stocks display a characteristic gait ataxia with 'foot-patting' behavior; despite their ataxia the mutant animals are healthy, long-lived, and breed normally. Breeding experiments confirmed that 153Gso and 154Gso mutations are allelic, and both fail to complement a known mutation hotfoot (ho), a Mmu6 mutation involving the glutamate receptor gene, Grid2, that is associated with a virtually identical phenotype. Our studies demonstrate that the 153Gso and 154Gso mutations disrupt the Grid2 gene at sites located more than 100 kb apart in intron 6 and intron 4 of the gene, respectively. The occurrence of two independent translocations from a relatively small colony within the same locus supports data suggesting the hypermutability of the Grid2 locus and suggest that the gene's large size make it an especially likely target for mutations involving genetic rearrangement.
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