ReviewJournal of neuro-oncology2004
Molecular pathogenesis of childhood brain tumors.
Review in Journal of neuro-oncology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Rodent models of tumours of the central nervous system.Molecular oncology · 2024Review
- [Pediatric intracranial tumors : Principles of diagnostics and treatment].Der Radiologe · 2014Review
- SHH, WNT, and NOTCH pathways in medulloblastoma: when cancer stem cells maintain self-renewal and differentiation properties.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- The clinical implications of medulloblastoma subgroups.Nature reviews. Neurology · 2012Review
- Low incidence of brain tumors among Ethiopian immigrants in Israel.Journal of neuro-oncology · 2011Article
- A pyrosequencing-based assay for the rapid detection of IDH1 mutations in clinical samples.The Journal of molecular diagnostics : JMD · 2010Article
- OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas.Cancer research · 2010Article
- Recurrent glioblastoma of childhood treated with bevacizumab: case report and molecular features.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2010Article
- The role of the membrane cytoskeleton cross-linker ezrin in medulloblastoma cells.Neuro-oncology · 2009Article
- Defining a role for Sonic hedgehog pathway activation in desmoplastic medulloblastoma by identifying GLI1 target genes.International journal of cancer · 2009Article
- Besides Purkinje cells and granule neurons: an appraisal of the cell biology of the interneurons of the cerebellar cortex.Histochemistry and cell biology · 2008Review
- Invasion suppressor cystatin E/M (CST6): high-level cell type-specific expression in normal brain and epigenetic silencing in gliomas.Laboratory investigation; a journal of technical methods and pathology · 2008Article
- Article
- Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma.Genes & development · 2008Article
- Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice.Developmental biology · 2008Article
- Embryonal tumor with abundant neuropil and true rosettes (ETANTR): report of a case with prominent neurocytic differentiation.Journal of neuro-oncology · 2007Article
- Medulloblastoma in a child with Duchenne muscular dystrophy.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2007Article
- Medulloblastoma: therapy and biologic considerations.Current neurology and neuroscience reports · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last decade, the molecular biology revolution has advanced considerably. These advances have enhanced our understanding of the genetic underpinnings of human brain tumors in general, and pediatric brain tumors in particular. We now know that many pediatric brain tumors arise from disturbances in developmentally regulated signaling pathways. The medulloblastoma, a tumor in which the developmental Hedgehog and WNT pathways have gone awry, is a prime example of this. New techniques in genetic engineering have allowed for the creation of sophisticated mouse models of brain tumors that recapitulate the human disease. Many laboratories are now using cDNA microarrays to study the expression level of thousands of genes that may be aberrantly expressed in brain tumors when compared to normal control cells. In the next decade, the use of several new molecular techniques to establish brain tumor diagnoses will likely become standard tools in the diagnostics and treatment stratification of children with central nervous system tumors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.