ArticleGenes and immunity2005
Genome screen in the French EGEA study: detection of linked regions shared or not shared by allergic rhinitis and asthma.
Article in Genes and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 38 citations in OpenAlex.
- Pathophysiological and molecular insights into allergic conjunctivitis: an expanding analysis of immunological endotypes.Frontiers in allergy · 2026Review
- Microenvironment modulation by key regulators of RNA N6-methyladenosine modification in respiratory allergic diseases.BMC pulmonary medicine · 2023Article
- Genetics and Epigenetics in Allergic Rhinitis.Genes · 2021Review
- Genetics of allergic diseases.Immunology and allergy clinics of North America · 2015Review
- A genome-wide search for linkage to allergic rhinitis in Danish sib-pair families.European journal of human genetics : EJHG · 2012Article
- The role of complement in the diagnosis and management of allergic rhinitis and allergic asthma.Current allergy and asthma reports · 2011Review
- Allergic rhinitis and genetic components: focus on Toll-like receptors (TLRs) gene polymorphism.The application of clinical genetics · 2010Article
- G/T substitution in intron 1 of the UNC13B gene is associated with increased risk of nephropathy in patients with type 1 diabetes.Diabetes · 2008Article
- Evidence for linkage of a new region (11p14) to eczema and allergic diseases.Human genetics · 2008Article
- Highly significant linkage to chromosome 3q13.31 for rhinitis and related allergic diseases.Journal of medical genetics · 2006Article
Corrections and comments
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Authors and funding
21 authors at 12 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the sample of 295 French EGEA families with at least one asthmatic subject, a genome screen was conducted to identify potential linkage regions specific either to allergic rhinitis (AR) or to asthma as well as those shared by the two diseases. Two binary rhinitis phenotypes based on (1) diagnosis (ARbin1) and (2) symptoms (ARbin2) and a categorical ordered trait (ARcat) were considered. Asthma phenotype was based on answers to a standardized questionnaire plus the presence of bronchial hyper-responsiveness. Linkage analyses were conducted using the maximum likelihood binomial (MLB) method. These analyses provided potential evidence for linkage to three regions in the whole sample: 1p31 for the phenotype defined by ARbin2 plus asthma (P=0.00016), 2q32 for ARbin2 (P=0.00016) and 3p24-p14 for ARcat (P=0.001). Two other regions were detected in the subset of 185 families with at most one asthmatic sib: 9p22 and 9q22-q34 for ARbin1 (P=0.001 and 0.0007, respectively). No region showed evidence for linkage to asthma without being also linked to AR. While 1p31 may contain a genetic determinant common to asthma and AR, 2q32, 3p24-p14, 9p22 and 9q22-q34 are more likely to harbor genetic factors specific to AR.
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