ArticleGenes and immunity2005
Direct sequence comparison of two divergent class I MHC natural killer cell receptor haplotypes.
Article in Genes and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- Article
- Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions.bioRxiv : the preprint server for biology · 2024Article
- Cis-regulatory evolution of the recently expanded Ly49 gene family.Nature communications · 2024Article
- Immunoreceptor tyrosine-based inhibitory motif-dependent functions of an MHC class I-specific NK cell receptor.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Murine Cytomegalovirus Disrupts Splenic Dendritic Cell SubsetsFrontiers in immunology · 2017Article
- Nucleosome Presence at AML-1 Binding Sites Inversely Correlates with Ly49 Expression: Revelations from an Informatics Analysis of Nucleosomes and Immune Cell Transcription Factors.PLoS computational biology · 2016Article
- Slp-76 is a critical determinant of NK-cell mediated recognition of missing-self targets.European journal of immunology · 2015Article
- Probabilistic bidirectional promoter switches: noncoding RNA takes control.Molecular therapy. Nucleic acids · 2014Article
- Ly49 receptors: innate and adaptive immune paradigms.Frontiers in immunology · 2014Review
- Impaired natural killer cell self-education and "missing-self" responses in Ly49-deficient mice.Blood · 2012Article
- Article
- Analysis of the mouse 129-strain Nkrp1-Clr gene cluster reveals conservation of genomic organization and functional receptor-ligand interactions despite significant allelic polymorphism.Immunogenetics · 2011Article
- Structural variation of the mouse natural killer gene complex.Genes and immunity · 2010Article
- Cytomegalovirus immunoevasin reveals the physiological role of "missing self" recognition in natural killer cell dependent virus control in vivo.The Journal of experimental medicine · 2010Article
- Evidence for high bi-allelic expression of activating Ly49 receptors.Nucleic acids research · 2009Article
- Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC.The Journal of experimental medicine · 2008Article
- NK gene complex dynamics and selection for NK cell receptors.Seminars in immunology · 2008Review
- Ly49 cluster sequence analysis in a mouse model of diabetes: an expanded repertoire of activating receptors in the NOD genome.Genes and immunity · 2008Article
- Identification of bidirectional promoters in the human KIR genes.Genes and immunity · 2007Article
- Complete elucidation of a minimal class I MHC natural killer cell receptor haplotype.Genes and immunity · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The murine Ly49 gene family encoding natural killer cell receptors for class I MHC is an example of a rapidly evolving cluster of immune response genes. Determining the genomic sequence of the 129S6/SvEvTac (129S6) Ly49 cluster and comparing it to the known sequence of the C57BL/6 (B6) region provided insight into the mechanisms of Ly49 gene evolution. 129S6 contains 20 Ly49, many of which are pseudogenes and 40% of the genes have no counterpart in the B6 genome. The difference in gene content between these two strains is primarily the result of distinct patterns of gene duplication. Phylogenetic analyses of individual exons showed that Ly49 genes form distinct sub-families and an ancestral haplotype can be surmised. Dotplot analysis supports limited allelism in the two haplotypes; however, large regions of variation punctuate these islands of co-linearity. These variable regions contain a high concentration of repetitive elements that are predicted to contribute to the dynamic evolution of this cluster. The extreme variation in Ly49 haplotype content between mouse strains provides a genetic explanation for the documented differences in natural killer cell phenotype, and also indicates that differences in natural killer cell function observed between B6 and 129-derived gene-targeted mice should be interpreted with caution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.