ArticleGenes and immunity2005
Differential cytokine genotype frequencies among Canadian Aboriginal and Caucasian populations.
Article in Genes and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 57 citations in OpenAlex.
- Inflammaging Markers in the Extremely Cold Climate: A Case Study of Yakutian Population.International journal of molecular sciences · 2024Article
- A comprehensive exploration of chronic kidney disease and dialysis in Canada's Indigenous population: from epidemiology to genetic influences.International urology and nephrology · 2024Review
- Genetic Susceptibility to Fungal Infections and Links to Human Ancestry.Frontiers in genetics · 2021Review
- Polymorphisms in the P2X7 receptor, and differential expression of Toll-like receptor-mediated cytokines and defensins, in a Canadian Indigenous group.Scientific reports · 2019Article
- Peripheral artery disease among Indigenous Canadians: What do we know?Canadian journal of surgery. Journal canadien de chirurgie · 2018Review
- Variation among populations in the immune protein composition of mother's milk reflects subsistence pattern.Evolution, medicine, and public health · 2018Article
- Exploring the risk factors for sudden infant deaths and their role in inflammatory responses to infection.Frontiers in immunology · 2015Review
- The Role of Infection and Inflammation in Stillbirths: Parallels with SIDS?Frontiers in immunology · 2015Review
- Statement on Seasonal Influenza Vaccine for 2013-2014: An Advisory Committee Statement (ACS) National Advisory Committee on Immunization (NACI).Canada communicable disease report = Releve des maladies transmissibles au Canada · 2013Article
- Association of common single-nucleotide polymorphisms in innate immune genes with differences in TLR-induced cytokine production in neonates.Genes and immunity · 2013Article
- Article
- Preliminary analysis of immune activation in early onset type 2 diabetes.International journal of circumpolar health · 2013Article
- STATEMENT ON SEASONAL INFLUENZA VACCINE FOR 2012-2013: An Advisory Committee Statement (ACS) National Advisory Committee on Immunization (NACI).Canada communicable disease report = Releve des maladies transmissibles au Canada · 2012Article
- Article
- Influence of socioeconomic status trajectories on innate immune responsiveness in children.PloS one · 2012Article
- Risk Factors for Alloimmunisation after red blood Cell Transfusions (R-FACT): a case cohort study.BMJ open · 2012Article
- The potential influence of KIR cluster profiles on disease patterns of Canadian Aboriginals and other indigenous peoples of the Americas.European journal of human genetics : EJHG · 2011Article
- Statement on Seasonal Influenza Vaccine for 2011-2012: An Advisory Committee Statement (ACS) National Advisory Committee on Immunization (NACI)Canada communicable disease report = Releve des maladies transmissibles au Canada · 2011Article
- Assessing inflammatory bowel disease-associated antibodies in Caucasian and First Nations cohorts.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2011Article
- Seasonal influenza vaccine and increased risk of pandemic A/H1N1‐related illness: first detection of the association in British Columbia, Canada.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic diversity related to the human immune response is a key factor in individual and population survival throughout human history. Population diversity in disease susceptibility and resistance have been identified and linked to differences in cytokine mRNA and protein expression levels. Polymorphisms in the regulatory regions of cytokine genes can influence gene transcription levels and they have been associated with susceptibility to, and/or severity of, autoimmune disorders such as rheumatoid arthritis, meningococcus and sepsis. It is reported here that in two study populations, Canadian Aboriginal individuals have a higher frequency of cytokine single-nucleotide polymorphisms favouring a low production of TNFalpha, IFNgamma and IL-10 and high production of IL-6 as compared to a Caucasian population. We postulate that the evolution of this unique cytokine genotype profile may be linked to the Aboriginal adaptation to selection pressures related to an environment in which helminthic, parasitic and fungal infections predominated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.