ArticleOncogene2005
A transient increase in the activity of Src-family kinases induced by cell detachment delays anoikis of intestinal epithelial cells.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- Membrane Curvature Activates Src kinase and Promotes Metastatic Cancer Cell Survival.bioRxiv : the preprint server for biology · 2026Article
- Proteomic Analysis of Src Family Kinase Phosphorylation States in Cancer Cells Suggests Deregulation of the Unique Domain.Molecular cancer research : MCR · 2021Article
- The NF2 tumor suppressor merlin interacts with Ras and RasGAP, which may modulate Ras signaling.Oncogene · 2019Article
- Phosphorylation of human TRM9L integrates multiple stress-signaling pathways for tumor growth suppression.Science advances · 2018Article
- Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment.International journal of molecular sciences · 2018Review
- Advancing Intestinal Organoid Technology Toward Regenerative Medicine.Cellular and molecular gastroenterology and hepatology · 2018Review
- From embryonic development to human diseases: The functional role of caveolae/caveolin.Birth defects research. Part C, Embryo today : reviews · 2016Review
- Phosphatidylinositol Phosphate 5-Kinase Iγ and Phosphoinositide 3-Kinase/Akt Signaling Couple to Promote Oncogenic Growth.The Journal of biological chemistry · 2015Article
- Activation of Lyn tyrosine kinase through decreased membrane cholesterol levels during a change in its membrane distribution upon cell detachment.The Journal of biological chemistry · 2014Article
- Src-mediated caveolin-1 phosphorylation regulates intestinal epithelial restitution by altering Ca(2+) influx after wounding.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- AEG-1 promotes anoikis resistance and orientation chemotaxis in hepatocellular carcinoma cells.PloS one · 2014Article
- A phase 1 study of gemcitabine combined with dasatinib in patients with advanced solid tumors.Investigational new drugs · 2013Article
- Caveolin-1 regulates endothelial adhesion of lung cancer cells via reactive oxygen species-dependent mechanism.PloS one · 2013Article
- Targeted subendothelial matrix oxidation by myeloperoxidase triggers myosin II-dependent de-adhesion and alters signaling in endothelial cells.Free radical biology & medicine · 2012Article
- RAP1GAP inhibits cytoskeletal remodeling and motility in thyroid cancer cells.Endocrine-related cancer · 2012Article
- Anoikis resistance: an essential prerequisite for tumor metastasis.International journal of cell biology · 2012Article
- FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing.PloS one · 2011Article
- Loss of tyrosine phosphatase-dependent inhibition promotes activation of tyrosine kinase c-Src in detached pancreatic cells.Molecular carcinogenesis · 2010Article
- Protective endogenous cyclic adenosine 5'-monophosphate signaling triggered by pemphigus autoantibodies.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells.Journal of cell science · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detachment of epithelial cells from the basement membrane (BM) induces apoptosis, a phenomenon now widely known as anoikis. Studies in mammary and intestinal epithelial cells have shown that the loss of attachment to the BM rapidly triggers reversible proapoptotic events from which the cells can recover if they reattach within a certain period. Thus, cells seem to be transiently protected from the initial detachment-induced proapoptotic events. The molecular mechanisms underlying such transient protection against anoikis are unknown. In this paper, we present evidence indicating that detachment of intestinal epithelial cells triggers a transient, yet significant increase in the activity of the tyrosine kinases c-Src and c-Fyn, and that this activation of Src-family kinases (SFK) contributes to the transient protection against anoikis in these cells. The protective signals from SFK are mediated by the PI3K pathway, and caveolin-1. In addition, we show that the MEK1-ERK1/2 pathway acts in a synergistic manner with SFK to protect intestinal epithelial cells from anoikis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.