Trial reportEuropean journal of clinical nutrition2005
Effect of dietary supplementation with conjugated linoleic acid on markers of calcium and bone metabolism in healthy adult men.
Trial report in European journal of clinical nutrition, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 63 citations in OpenAlex.
- The Effect of Conjugated Linoleic Acid Supplementation on Densitometric Parameters in Overweight and Obese Women-A Randomised Controlled Trial.Medicina (Kaunas, Lithuania) · 2023Trial
- Trial
- The relationship between the zinc nutritive status and biochemical markers of bone turnover in older European adults: the ZENITH study.European journal of clinical nutrition · 2005Trial
- Enhancing Bone Health with Conjugated Linoleic Acid: Mechanisms, Challenges, and Innovative Strategies.Nutrients · 2025Review
- Molecular Interactions between Dietary Lipids and Bone Tissue during Aging.International journal of molecular sciences · 2021Review
- Conjugated linoleic acid prompts bone formation in ovariectomized osteoporotic rats and weakens osteoclast formation after treatment with ultraviolet B.Annals of translational medicine · 2021Article
- Article
- Drugs or diet?--Developing novel therapeutic strategies targeting the free fatty acid family of GPCRs.British journal of pharmacology · 2013Review
- Interaction between dietary conjugated linoleic acid and calcium supplementation affecting bone and fat mass.Journal of bone and mineral metabolism · 2011Article
- Conjugated linoleic acids mediate insulin release through islet G protein-coupled receptor FFA1/GPR40.The Journal of biological chemistry · 2011Article
- Impact of conjugated linoleic acid on bone physiology: proposed mechanism involving inhibition of adipogenesis.Nutrition reviews · 2011Review
- Conjugated linoleic acids as functional food: an insight into their health benefits.Nutrition & metabolism · 2009Article
- Effects of 9cis,11trans and 10trans,12cis CLA on osteoclast formation and activity from human CD14+ monocytes.Lipids in health and disease · 2009Article
- Beneficial effects of conjugated linoleic acid and exercise on bone of middle-aged female mice.Journal of bone and mineral metabolism · 2008Article
- Determinants of vitamin D status in adult Crohn's disease patients, with particular emphasis on supplemental vitamin D use.European journal of clinical nutrition · 2006Article
- Effects of cis-9,trans-11 CLA in rats at intake levels reported for breast-fed infants.Lipids · 2006Article
- Effects of conjugated linoleic acid and exercise on bone mass in young male Balb/C mice.Lipids in health and disease · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionConjugated linoleic acid (CLA) has been shown to positively influence calcium and bone metabolism in experimental animals and cells in culture, but there are limited human data available.
objectiveTo investigate the effect of CLA supplementation on biomarkers of calcium and bone metabolism in healthy adult males.
designThe study consisted of a double-blind, placebo-controlled trial in which 60 healthy adult males (aged 39-64 y) were randomly assigned to receive daily either 3.0 g CLA isomer blend (50:50% cis-9,trans-11:trans-10,cis-12 isomers) or a palm/bean oil blend (placebo) for 8 weeks. Urine and blood samples were collected at weeks 0 and 8 and were analysed for biomarkers of calcium and bone metabolism.
resultsSupplementation with CLA or placebo for 8 weeks had no significant effects on markers of bone formation (serum osteocalcin and bone-specific alkaline phosphatase) or bone resorption (serum C-telopeptide-related fraction of type 1 collagen degradation products, urinary N-telopeptide-related fraction of type 1 collagen degradation products, urinary pyridinoline and deoxypyridinoline), or on serum or urinary calcium levels. Baseline levels of these biochemical parameters were similar in both groups of subjects. While the placebo had no effect, CLA supplementation resulted in a three-fold increase (P<0.00001) in cis-9,trans-11 CLA isomer in total plasma lipids.
conclusionUnder the conditions tested in this double-blind, placebo-controlled trial in adult men, a CLA supplement of mixed isomers did not affect markers of calcium or bone metabolism. Further investigation of the effects of CLA on calcium and bone metabolism in other gender- and age-groups is warranted.
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