ArticleAntimicrobial agents and chemotherapy2005
AcrAB efflux pump plays a role in decreased susceptibility to tigecycline in Morganella morganii.
Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Tigecycline for the treatment of multidrug-resistant Enterobacteriaceae: a systematic review of the evidence from microbiological and clinical studies.The Journal of antimicrobial chemotherapy · 2008Pooled it
- Real-time PCR and statistical analyses of acrAB and ramA expression in clinical isolates of Klebsiella pneumoniae.Antimicrobial agents and chemotherapy · 2008Trial
- Emergence of NDM-type metallo-β-lactamase and ArmA 16S rRNA methylase co-producing Morganella morganii in Myanmar.BMC infectious diseases · 2026Article
- Genomic Analysis of Two Histamine-Producing Strains Isolated from Yellowfin Tuna.Foods (Basel, Switzerland) · 2025Article
- Mechanisms of tigecycline resistance in Gram-negative bacteria: A narrative review.Engineering microbiology · 2024Review
- Efflux Pumps and Different Genetic Contexts ofInternational journal of molecular sciences · 2023Article
- Tigecycline antibacterial activity, clinical effectiveness, and mechanisms and epidemiology of resistance: narrative review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022Review
- Genetic and Phenotypic Diversity ofFrontiers in microbiology · 2021Article
- Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin.Antibiotics (Basel, Switzerland) · 2020Article
- Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 inAntimicrobial agents and chemotherapy · 2019Article
- Mode of Action of the Monobactam LYS228 and Mechanisms DecreasingAntimicrobial agents and chemotherapy · 2018Article
- Tetracycline Antibiotics and Resistance.Cold Spring Harbor perspectives in medicine · 2016Review
- The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.Clinical microbiology reviews · 2015Review
- Interaction of antibacterial compounds with RND efflux pumps in Pseudomonas aeruginosa.Frontiers in microbiology · 2015Review
- Genomics of KPC-producing Klebsiella pneumoniae sequence type 512 clone highlights the role of RamR and ribosomal S10 protein mutations in conferring tigecycline resistance.Antimicrobial agents and chemotherapy · 2014Article
- Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?Clinical microbiology reviews · 2013Review
- Tigecycline challenge triggers sRNA production in Salmonella enterica serovar Typhimurium.BMC microbiology · 2012Article
- Genetic regulation of the ramA locus and its expression in clinical isolates of Klebsiella pneumoniae.International journal of antimicrobial agents · 2011Article
- In vitro selection of ramR and soxR mutants overexpressing efflux systems by fluoroquinolones as well as cefoxitin in Klebsiella pneumoniae.Antimicrobial agents and chemotherapy · 2011Article
- ramR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline.Antimicrobial agents and chemotherapy · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transposon mutagenesis of a clinical isolate of Morganella morganii, G1492 (tigecycline MIC of 4 microg/ml), yielded two insertion knockout mutants for which tigecycline MICs were 0.03 microg/ml. Transposon insertions mapped to acrA, which is constitutively overexpressed in G1492, suggesting a role of the AcrAB efflux pump in decreased susceptibility to tigecycline in M. morganii.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.