ArticleAntimicrobial agents and chemotherapy2005
Tetracycline-resistant clinical Helicobacter pylori isolates with and without mutations in 16S rRNA-encoding genes.
Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Molecular Detection Technologies for Helicobacter pylori Antibiotic Resistance: Current Status and Clinical Implications.Current microbiology · 2026Review
- Overcoming antibiotic-resistantWorld journal of gastroenterology · 2025Review
- Antibiotic Resistance ofJournal of Korean medical science · 2024Review
- Molecular tools of antibiotic resistance forFrontiers in gastroenterology (Lausanne, Switzerland) · 2024Review
- Antibiotic resistance in Helicobacter pylori: From potential biomolecular mechanisms to clinical practice.Journal of clinical laboratory analysis · 2023Review
- Clinical Implication of Drug Resistance forAntibiotics (Basel, Switzerland) · 2022Review
- Helicobacter pylori Infection, Its Laboratory Diagnosis, and Antimicrobial Resistance: a Perspective of Clinical Relevance.Clinical microbiology reviews · 2022Review
- Helicobacter pylori infection and antibiotic resistance - from biology to clinical implications.Nature reviews. Gastroenterology & hepatology · 2021Review
- Predicting rifampicin resistance mutations in bacterial RNA polymerase subunit beta based on majority consensus.BMC bioinformatics · 2021Article
- Next Generation Sequencing for the Prediction of the Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2021Review
- The Prevalence of Multidrug Resistance ofAntibiotics (Basel, Switzerland) · 2020Article
- Eradication Treatment ofInfection and drug resistance · 2020Article
- Genetic Determinants and Prediction of Antibiotic Resistance Phenotypes inJournal of clinical medicine · 2019Article
- A Newly Discovered Drug Resistance GeneInfection and drug resistance · 2019Article
- Prospects for the Use of New Technologies to Combat Multidrug-Resistant Bacteria.Frontiers in pharmacology · 2019Article
- Multiple mutations and increased RNA expression in tetracycline-resistant Streptococcus pneumoniae as determined by genome-wide DNA and mRNA sequencing.The Journal of antimicrobial chemotherapy · 2015Article
- 16S rRNA gene mutations associated with decreased susceptibility to tetracycline in Mycoplasma bovis.Antimicrobial agents and chemotherapy · 2015Article
- Detection of genotypic clarithromycin-resistant Helicobacter pylori by string tests.World journal of gastroenterology · 2014Article
- Absence of Helicobacter pylori high tetracycline resistant 16S rDNA AGA926-928TTC genotype in gastric biopsy specimens from dyspeptic patients of a city in the interior of São Paulo, Brazil.BMC gastroenterology · 2012Article
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6 authors.
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Abstract
Tetracycline-resistant Helicobacter pylori strains have been increasingly reported worldwide. However, only a small number of tetracycline-resistant strains have been studied with regard to possible mechanisms of resistance and those studies have focused on mutations in the tetracycline binding sites of 16S rRNA-encoding genes. We here report studies of 41 tetracycline-resistant H. pylori strains (tetracycline MICs, 4 to 32 microg/ml) from North America (n = 12) and from East Asia (n = 29). DNA sequence analyses of 16S rRNA-encoding genes revealed that 22 (54%) of the resistant isolates carried one of five different single-nucleotide substitutions (CGA, GGA, TGA, AGC, or AGT) at the putative tetracycline binding site (AGA(965-967)). Single-nucleotide substitutions were associated with reduced ribosomal binding and with slightly increased tetracycline MICs (1 to 2 microg/ml). The 19 tetracycline-resistant isolates with no detectable mutations in the tetracycline binding site had normal tetracycline-ribosome binding. All tetracycline-resistant isolates, including those with and those without mutations in the tetracycline binding site, showed decreased accumulation of tetracycline. These results suggest that tetracycline resistance is multifactorial, involving alterations both in ribosomal binding and in membrane permeability.
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