ArticleAntimicrobial agents and chemotherapy2005
Mutations in folP associated with elevated sulfonamide MICs for Neisseria meningitidis clinical isolates from five continents.
Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 43 citations in OpenAlex.
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- The novel 2024 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations and superseded WHO N. gonorrhoeae reference strains-phenotypic, genetic and reference genome characterization.The Journal of antimicrobial chemotherapy · 2024Article
- Recommendation of a standardized broth microdilution method for antimicrobial susceptibility testing ofJournal of clinical microbiology · 2024Article
- Continuing genomic evolution of theMicrobial genomics · 2023Review
- Whole-Genome and Plasmid Comparative Analysis of Campylobacter jejuni from Human Patients in Toyama, Japan, from 2015 to 2019.Microbiology spectrum · 2023Article
- Carriage ofInfection and drug resistance · 2022Article
- Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures.Microorganisms · 2021Article
- A community-driven resource for genomic epidemiology and antimicrobial resistance prediction of Neisseria gonorrhoeae at Pathogenwatch.Genome medicine · 2021Article
- Applications of genomics to slow the spread of multidrug-resistant Neisseria gonorrhoeae.Annals of the New York Academy of Sciences · 2019Review
- Mechanisms of Bacterial Resistance to Antimicrobial Agents.Microbiology spectrum · 2018Article
- The novel 2016 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations: phenotypic, genetic and reference genome characterization.The Journal of antimicrobial chemotherapy · 2016Article
- Phasevarions mediate epigenetic regulation of antimicrobial susceptibility in Neisseria meningitidis.Antimicrobial agents and chemotherapy · 2014Article
- Article
- Role of Neisseria meningitidis PorA and PorB expression in antimicrobial susceptibility.Antimicrobial agents and chemotherapy · 2014Article
- Resolution of a meningococcal disease outbreak from whole-genome sequence data with rapid Web-based analysis methods.Journal of clinical microbiology · 2012Article
- Multilaboratory evaluation of disk diffusion antimicrobial susceptibility testing of Neisseria meningitidis isolates.Journal of clinical microbiology · 2006Article
- Susceptibility of Neisseria meningitidis to 16 antimicrobial agents and characterization of resistance mechanisms affecting some agents.Journal of clinical microbiology · 2005Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Sulfonamide resistance in meningococci is associated with mutations in the chromosomal gene folP, which encodes dihydropteroate synthase. Several mutations associated with resistance have been previously described, including amino acid substitutions at codons 31 and 194, a glycine-serine insertion at codons 195 and 196, and, recently, an additional mutation at nucleotide 682 (C682A). In this study, sulfisoxazole MICs were determined for 424 geographically diverse clinical isolates of Neisseria meningitidis, including all major subtypes. A subset of 134 isolates with MICs ranging from 0.5 to >64 microg/ml were assayed for the C682A mutation by real-time PCR, and 25 isolates were selected for folP gene sequencing. All isolates for which the sulfisoxazole MIC was >/=8 possessed the C682A mutation by real-time PCR or folP sequencing, and 34 of 35 isolates with a MIC of </=2 lacked this mutation. Of 16 sequenced isolates for which the sulfisoxazole MIC was >/=4, 15 possessed previously described mutations, including 10 at codon 31, 1 at codon 194, and 4 with the 2-amino-acid insertion codons 195 and 196; all 16 possessed the C682A mutation. The C682A mutation predicted elevated sulfonamides MICs for a large number of geographically diverse clinical isolates of meningococci. Detection of this mutation by real-time PCR or other methods may allow more wide-scale detection of meningococcal isolates with for which the sulfonamide MICs are elevated without resorting to multiple assays or folP gene sequencing, providing a simple, high-throughput screening method for use in public health and epidemiologic settings.
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