ArticleNucleic acids research2005
Noncoding DNA, isochores and gene expression: nucleosome formation potential.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 87 citations in OpenAlex.
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- Uptake and function of membrane-destabilizing cationic nanogels for intracellular drug delivery.Bioengineering & translational medicine · 2019Article
- DNA helix: the importance of being AT-rich.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- On the genome base composition of teleosts: the effect of environment and lifestyle.BMC genomics · 2016Article
- Implications of human genome structural heterogeneity: functionally related genes tend to reside in organizationally similar genomic regions.BMC genomics · 2014Article
- Length and GC content variability of introns among teleostean genomes in the light of the metabolic rate hypothesis.PloS one · 2014Article
- The footprint of metabolism in the organization of mammalian genomes.BMC genomics · 2012Article
- The evolution of intron size in amniotes: a role for powered flight?Genome biology and evolution · 2012Article
- Tandemly repeated DNA families in the mouse genome.BMC genomics · 2011Article
- Nucleosome DNA sequence structure of isochores.BMC genomics · 2011Article
- Chromatin organization in sperm may be the major functional consequence of base composition variation in the human genome.PLoS genetics · 2011Article
- Relationship between amino acid composition and gene expression in the mouse genome.BMC research notes · 2011Article
- In plants, expression breadth and expression level distinctly and non-linearly correlate with gene structure.Biology direct · 2009Article
- Comparative analysis of distinct non-coding characteristics potentially contributing to the divergence of human tissue-specific genes.Genetica · 2009Article
- ContDist: a tool for the analysis of quantitative gene and promoter properties.BMC bioinformatics · 2009Article
- The impact of recombination on nucleotide substitutions in the human genome.PLoS genetics · 2008Article
- Both selective and neutral processes drive GC content evolution in the human genome.BMC evolutionary biology · 2008Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nucleosome formation potential of introns, intergenic spacers and exons of human genes is shown here to negatively correlate with among-tissues breadth of gene expression. The nucleosome formation potential is also found to negatively correlate with the GC content of genomic sequences; the slope of regression line is steeper in exons compared with noncoding DNA (introns and intergenic spacers). The correlation with GC content is independent of sequence length; in turn, the nucleosome formation potential of introns and intergenic spacers positively (albeit weakly) correlates with sequence length independently of GC content. These findings help explain the functional significance of the isochores (regions differing in GC content) in the human genome as a result of optimization of genomic structure for epigenetic complexity and support the notion that noncoding DNA is important for orderly chromatin condensation and chromatin-mediated suppression of tissue-specific genes.
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