ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Target-specific regulation of synaptic amplitudes in the neocortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Reduced expression of N-methyl-D-aspartate receptor and calcium signaling genes in gray matter is associated with cancer-related cognitive impairment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Regulation of NMDAR activation efficiency by environmental factors and subunit composition.The Journal of general physiology · 2025Article
- Layer-specific distribution and expression pattern of AMPA- and NMDA-type glutamate receptors in the barrel field of the adult rat somatosensory cortex: a quantitative electron microscopic analysis.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Lactate Attenuates Synaptic Transmission and Affects Brain Rhythms Featuring High Energy Expenditure.iScience · 2020Article
- Overexpression of Calretinin Enhances Short-Term Synaptic Depression.Frontiers in cellular neuroscience · 2019Article
- The Ever-Growing Puzzle of Asynchronous Release.Frontiers in cellular neuroscience · 2019Review
- Input-specific maturation of NMDAR-mediated transmission onto parvalbumin-expressing interneurons in layers 2/3 of the visual cortex.Journal of neurophysiology · 2018Article
- Target-cell-specific Short-term Plasticity Reduces the Excitatory Drive onto CA1 Interneurons Relative to Pyramidal Cells During Physiologically-derived Spike Trains.Neuroscience · 2018Article
- The Role of Polyamine-Dependent Facilitation of Calcium Permeable AMPARs in Short-Term Synaptic Enhancement.Frontiers in cellular neuroscience · 2018Review
- Layer-Specific Organization of Local Excitatory and Inhibitory Synaptic Connectivity in the Rat Presubiculum.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Interplay between synchronization of multivesicular release and recruitment of additional release sites support short-term facilitation at hippocampal mossy fiber to CA3 pyramidal cells synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Synapse-associated protein 97 regulates the membrane properties of fast-spiking parvalbumin interneurons in the visual cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- A target cell-specific role for presynaptic Fmr1 in regulating glutamate release onto neocortical fast-spiking inhibitory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Peripheral nerve damage does not alter release properties of developing central trigeminal afferents.Journal of neurophysiology · 2011Article
- Glutamate receptor subtypes mediating synaptic activation of prefrontal cortex neurons: relevance for schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Multivesicular release differentiates the reliability of synaptic transmission between the visual cortex and the somatosensory cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Developmental alterations in the functional properties of excitatory neocortical synapses.The Journal of physiology · 2009Review
- Conditional bursting enhances resonant firing in neocortical layer 2-3 pyramidal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Selective, state-dependent activation of somatostatin-expressing inhibitory interneurons in mouse neocortex.Journal of neurophysiology · 2008Article
- Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome.Journal of neurophysiology · 2008Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In layers 2/3 in the rat visual cortex, glutamatergic synapses, between pyramidal neurons and GABAergic interneurons, show target-specific depression or facilitation. To study the mechanisms regulating these short-term synaptic modifications, we recorded from synaptically connected pyramidal neurons (presynaptic) and multipolar or bitufted interneurons (postsynaptic). Evoked AMPA receptor (AMPAR)- or NMDA receptor (NMDAR)-mediated EPSCs were pharmacologically isolated at these pyramidal-to-interneuron synapses while altering release probability (P(r)) by changing the extracellular Ca2+ concentration ([Ca2+]o). At the pyramidal-to-multipolar synapse, which shows paired-pulse depression, elevation of [Ca2+]o from physiological concentrations (2 mm) to 3 mm increased the amplitude of the initial AMPAR-mediated EPSC and enhanced paired-pulse depression. In contrast, the initial NMDAR-mediated EPSC did not change in amplitude with raised P(r) nor was paired-pulse depression altered. This lack of an increase of NMDAR-mediated currents is not a result of Ca2+-dependent effects on the NMDAR. Rather, at the pyramidal-to-multipolar synapse, raised P(r) increases the transient glutamate concentration at individual release sites, possibly reflecting multivesicular release. In contrast, at the pyramidal-to-bitufted synapse, which shows facilitation, AMPAR- and NMDAR-meditated EPSCs showed parallel increases in response to raised P(r). Thus, our results reveal differential recruitment of AMPA and NMDARs at depressing and facilitating synapses in layers 2/3 of the cortex and suggest that the mechanisms regulating dynamic aspects of synaptic transmission are target specific.
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Registered trials
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