ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Mechanisms of rhythm generation in a spinal locomotor network deprived of crossed connections: the lamprey hemicord.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 134 citations in OpenAlex.
- Cell-type-specific origins of locomotor rhythmicity at different speeds in larval zebrafish.eLife · 2024Article
- Spinal Interneurons: Diversity and Connectivity in Motor Control.Annual review of neuroscience · 2023Review
- Article
- How Does the Central Nervous System for Posture and Locomotion Cope With Damage-Induced Neural Asymmetry?Frontiers in systems neuroscience · 2022Review
- The serotonin reuptake blocker citalopram destabilizes fictive locomotor activity in salamander axial circuits through 5-HTJournal of neurophysiology · 2020Article
- Reproducing Five Motor Behaviors in a Salamander Robot With Virtual Muscles and a Distributed CPG Controller Regulated by Drive Signals and Proprioceptive Feedback.Frontiers in neurorobotics · 2020Article
- Hierarchical control of locomotion by distinct types of spinal V2a interneurons in zebrafish.Nature communications · 2019Article
- Control of transitions between locomotor-like and paw shake-like rhythms in a model of a multistable central pattern generator.Journal of neurophysiology · 2018Article
- Response: Commentary: Elimination of Left-Right Reciprocal Coupling in the Adult Lamprey Spinal Cord Abolishes the Generation of Locomotor Activity.Frontiers in neural circuits · 2018Article
- Commentary: Elimination of Left-Right Reciprocal Coupling in the Adult Lamprey Spinal Cord Abolishes the Generation of Locomotor Activity.Frontiers in neural circuits · 2018Article
- Delineating the Diversity of Spinal Interneurons in Locomotor Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Elimination of Left-Right Reciprocal Coupling in the Adult Lamprey Spinal Cord Abolishes the Generation of Locomotor Activity.Frontiers in neural circuits · 2017Article
- Microcircuits in respiratory rhythm generation: commonalities with other rhythm generating networks and evolutionary perspectives.Current opinion in neurobiology · 2016Review
- Rigidity and Flexibility: The Central Basis of Inter-Leg Coordination in the Locust.Frontiers in neural circuits · 2016Article
- Premotor spinal network with balanced excitation and inhibition during motor patterns has high resilience to structural division.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Optogenetic activation of excitatory premotor interneurons is sufficient to generate coordinated locomotor activity in larval zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Optogenetic dissection reveals multiple rhythmogenic modules underlying locomotion.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Inhibitory feedback promotes stability in an oscillatory network.Journal of neural engineering · 2011Article
- Flexibility in the patterning and control of axial locomotor networks in lamprey.Integrative and comparative biology · 2011Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spinal network coordinating locomotion in the lamprey serves as a model system, in which it has been possible to elucidate connectivity and cellular mechanisms using the isolated spinal cord. Locomotor burst activity alternates between the left and right side of a segment through reciprocal inhibition. We have recently shown that the burst generation itself in a hemisegment does not require inhibitory mechanisms. The focus of this study is the intrinsic operation of this hemisegmental burst-generating component of the locomotor network. Brief electrical stimulation (0.3 s) of the hemicord evokes long-lasting bouts (>2 min) of bursts (2-15 Hz) in the mid to high-frequency range of locomotion. Bout release is an all-or-none phenomenon requiring a threshold intensity of stimulation and glutamatergic transmission within a population of excitatory interneurons, with axons extending over several segments. The progressive activity-dependent decrease in burst frequency that takes place during a bout is followed by a slow recovery process lasting >20 min. Intracellular recordings of single motoneurons, excitatory interneurons, and inhibitory interneurons show that locomotor bouts, in general, are accompanied by a marked depolarization. Membrane potential oscillations and spikes occur in phase with the ventral root (VR) bursts. Active motoneurons and interneurons fire one spike per VR burst, as also confirmed by axonal recordings. Thus, the reciprocal inhibition between opposite hemisegments in the intact cord not only ensures left-right alternation and lowers the locomotor frequency but also promotes a shift from single to multiple action potentials per cycle in network neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.