ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Differential effects of cerebellar inactivation on eyeblink conditioned excitation and inhibition.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 54 citations in OpenAlex.
- The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning.Biology · 2024Review
- Dynamic Changes in Local Activity and Network Interactions among the Anterior Cingulate, Amygdala, and Cerebellum during Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Eyeblink tract tracing with two strains of herpes simplex virus 1.Brain research · 2022Article
- Amygdala central nucleus modulation of cerebellar learning in female rats.Behavioral neuroscience · 2021Article
- Sleep deprivation directly following eyeblink-conditioning impairs memory consolidation.Neurobiology of learning and memory · 2020Article
- Changes in cerebellar intrinsic neuronal excitability and synaptic plasticity result from eyeblink conditioning.Neurobiology of learning and memory · 2019Review
- Article
- Reevaluating the ability of cerebellum in associative motor learning.Scientific reports · 2019Article
- Changes in membrane properties of rat deep cerebellar nuclear projection neurons during acquisition of eyeblink conditioning.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Amygdala central nucleus modulation of cerebellar learning with a visual conditioned stimulus.Neurobiology of learning and memory · 2018Article
- Dynamic modulation of activity in cerebellar nuclei neurons during pavlovian eyeblink conditioning in mice.eLife · 2017Article
- Cross-modal savings in the contralateral eyelid conditioned response.Behavioral neuroscience · 2015Article
- Cerebellar learning mechanisms.Brain research · 2015Review
- Medial auditory thalamus is necessary for acquisition and retention of eyeblink conditioning to cochlear nucleus stimulation.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Cerebellar-dependent expression of motor learning during eyeblink conditioning in head-fixed mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Localization of the cerebellar cortical zone mediating acquisition of eyeblink conditioning in rats.Neurobiology of learning and memory · 2014Article
- Translational approach to behavioral learning: lessons from cerebellar plasticity.Neural plasticity · 2013Review
- Deep cerebellar nuclei play an important role in two-tone discrimination on delay eyeblink conditioning in C57BL/6 mice.PloS one · 2013Article
- Conditioned inhibition in a rodent model of attention-deficit/hyperactivity disorder.Behavioral neuroscience · 2011Article
- Retention and extinction of delay eyeblink conditioning are modulated by central cannabinoids.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The neural mechanisms underlying excitatory and inhibitory eyeblink conditioning were compared using muscimol inactivation of the cerebellum. In experiment 1, rats were given saline or muscimol infusions into the anterior interpositus nucleus ipsilateral to the conditioned eye before each of four daily excitatory conditioning sessions. Postinfusion testing continued for four more excitatory conditioning sessions. All rats were given a final test session after muscimol infusions. The muscimol infusions inactivated the cerebellar nuclei, lateral anterior lobe, crus I, rostral crus II, and lobule HVI ipsilateral to the conditioned eye. Acquisition of excitatory conditioning was completely prevented by muscimol inactivation. In experiment 2, there were four experimental phases. Phase 1 consisted of excitatory conditioning. In phase 2, rats were given saline or muscimol infusions before conditioned inhibition training. Phase 3 consisted of continued conditioned inhibition training with no drug infusions. In phase 4, all rats received a retardation test in which the inhibitory stimulus was paired with the unconditioned stimulus. Muscimol infusions blocked the expression of conditioned responses during phase 2. However, robust conditioned inhibition was evident in phases 3 and 4. The findings indicate that conditioned excitation and inhibition depend on different mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.