ArticleMolecular biology of the cell2005
Rab8 regulates the actin-based movement of melanosomes.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 64 citations in OpenAlex.
- Article
- Melanocore uptake by keratinocytes occurs through phagocytosis and involves protease-activated receptor-2 internalization.Traffic (Copenhagen, Denmark) · 2022Article
- Effect of fatty acids on melanogenesis and tumor cell growth in melanoma cells.Journal of lipid research · 2019Article
- Exploring the iceberg: Prospects of coordinated myosin V and actin assembly functions in transport processes.Small GTPases · 2019Review
- The Role of the Cytoskeleton and Myosin-Vc in the Targeting of KCa3.1 to the Basolateral Membrane of Polarized Epithelial Cells.Frontiers in physiology · 2016Article
- Myosin vc interacts with Rab32 and Rab38 proteins and works in the biogenesis and secretion of melanosomes.The Journal of biological chemistry · 2014Article
- Article
- Article
- Mechanisms of protein delivery to melanosomes in pigment cells.Physiology (Bethesda, Md.) · 2012Review
- Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane.Circulation research · 2012Article
- RAB8 enhances TMEM205-mediated cisplatin resistance.Pharmaceutical research · 2012Article
- Walking to work: roles for class V myosins as cargo transporters.Nature reviews. Molecular cell biology · 2011Review
- Semi-automated analysis of organelle movement and membrane content: understanding rab-motor complex transport function.Traffic (Copenhagen, Denmark) · 2011Article
- A C2 domain protein kinase initiates phagocytosis in the protozoan parasite Entamoeba histolytica.Nature communications · 2011Article
- Small G proteins as key regulators of pancreatic digestive enzyme secretion.American journal of physiology. Endocrinology and metabolism · 2009Review
- The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.Molecular biology of the cell · 2008Article
- Lysosome-related organelles: driving post-Golgi compartments into specialisation.Current opinion in cell biology · 2007Review
- Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective.Cellular signalling · 2007Review
- The ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epithelium.Traffic (Copenhagen, Denmark) · 2007Article
- Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.The EMBO journal · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Rab GTPases have been implicated in the regulation of specific microtubule- and actin-based motor proteins. We devised an in vitro motility assay reconstituting the movement of melanosomes on actin bundles in the presence of ATP to investigate the role of Rab proteins in the actin-dependent movement of melanosomes. Using this assay, we confirmed that Rab27 is required for the actin-dependent movement of melanosomes, and we showed that a second Rab protein, Rab8, also regulates this movement. Rab8 was partially associated with mature melanosomes. Expression of Rab8Q67L perturbed the cellular distribution and increased the frequency of microtubule-independent movement of melanosomes in vivo. Furthermore, anti-Rab8 antibodies decreased the number of melanosomes moving in vitro on actin bundles, whereas melanosomes isolated from cells expressing Rab8Q67L exhibited 70% more movements than wild-type melanosomes. Together, our observations suggest that Rab8 is involved in regulating the actin-dependent movement of melanosomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.