ArticleMolecular biology of the cell2005
Identification of xenopus CENP-A and an associated centromeric DNA repeat.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Attribute Network-based Ranking (ANeR) identifies conserved translational fingerprints of M-phase.Nucleic acids research · 2026Article
- Large tandem repeats of grass frog (Rana temporaria) in silico and in situ.BMC genomics · 2025Article
- Neural regulation of H3K27me3 during the induction of patterning competency in regenerating Axolotl limb cells.Communications biology · 2025Article
- Conserved chromatin and repetitive patterns reveal slow genome evolution in frogs.Nature communications · 2024Article
- Article
- Identification and characterization of centromeric sequences inGenome research · 2021Article
- Article
- Centromere Biology: Transcription Goes on Stage.Molecular and cellular biology · 2018Review
- Trimethylation of Histone 3 lysine 27 (H3K27me3) ChIP-PCR and transcriptional expression data of Ef1-alpha, cyp26A, HoxC10, HoxD10 and HoxD11 in the Xenopus XTC cell line.Data in brief · 2017Article
- Review
- Centromeric Non-coding Transcription: Opening the Black Box of Chromosomal Instability?Current genomics · 2017Review
- Mitotic noncoding RNA processing promotes kinetochore and spindle assembly in Xenopus.The Journal of cell biology · 2016Article
- Centromeric Transcription Regulates Aurora-B Localization and Activation.Cell reports · 2016Article
- Identification of the centromeric repeat in the threespine stickleback fish (Gasterosteus aculeatus).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Article
- RNA stimulates Aurora B kinase activity during mitosis.PloS one · 2014Article
- High-resolution mapping and transcriptional activity analysis of chicken centromere sequences on giant lampbrush chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- Article
- Flexibility of centromere and kinetochore structures.Trends in genetics : TIG · 2012Review
- Organization and molecular evolution of CENP-A--associated satellite DNA families in a basal primate genome.Genome biology and evolution · 2011Article
- Chickens possess centromeres with both extended tandem repeats and short non-tandem-repetitive sequences.Genome research · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kinetochores are the proteinaceous complexes that assemble on centromeric DNA and direct eukaryotic chromosome segregation. The mechanisms by which higher eukaryotic cells define centromeres are poorly understood. Possible molecular contributors to centromere specification include the underlying DNA sequences and epigenetic factors such as binding of the centromeric histone centromere protein A (CENP-A). Frog egg extracts are an attractive system for studying centromere definition and kinetochore assembly. To facilitate such studies, we cloned a Xenopus laevis homologue of CENP-A (XCENP-A). We identified centromere-associated DNA sequences by cloning fragments of DNA that copurified with XCENP-A by chromatin immunoprecipitation. XCENP-A associates with frog centromeric repeat 1 (Fcr1), a 174-base pair repeat containing a possible CENP-B box. Southern blots of partially digested genomic DNA revealed large ordered arrays of Fcr1 in the genome. Fluorescent in situ hybridization with Fcr1 probes stained most centromeres in cultured cells. By staining lampbrush chromosomes, we specifically identified the 11 (of 18) chromosomes that stain consistently with Fcr1 probes.
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