ArticleClinical & experimental metastasis2004
Resveratrol inhibits hepatoma cell invasion by suppressing gene expression of hepatocyte growth factor via its reactive oxygen species-scavenging property.
Article in Clinical & experimental metastasis, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 57 citations in OpenAlex.
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- Anti-hyperuricemic effect of taxifolin in cultured hepatocytes and model mice.Cytotechnology · 2017Article
- Quercetin, a Lead Compound against Type 2 Diabetes Ameliorates Glucose Uptake via AMPK Pathway in Skeletal Muscle Cell Line.Frontiers in pharmacology · 2017Article
- Antiproliferative and anti-invasive effect of piceatannol, a polyphenol present in grapes and wine, against hepatoma AH109A cells.Journal of biomedicine & biotechnology · 2012Article
- Hypoglycemic effect of resveratrol in type 2 diabetic model db/db mice and its actions in cultured L6 myotubes and RIN-5F pancreatic β-cells.Journal of clinical biochemistry and nutrition · 2011Article
- Anti-invasive activity of α-tocopherol against hepatoma cells in culture via protein kinase C inhibition.Journal of clinical biochemistry and nutrition · 2011Article
- Herbal medicine and hepatocellular carcinoma: applications and challenges.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Inhibitory effect of gingerol on the proliferation and invasion of hepatoma cells in culture.Cytotechnology · 2008Article
- Resveratrol: a review of preclinical studies for human cancer prevention.Toxicology and applied pharmacology · 2007Review
- Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells.Neoplasia (New York, N.Y.) · 2007Article
- Inhibitory effect of ascorbic Acid on the proliferation and invasion of hepatoma cells in culture.Cytotechnology · 2005Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resveratrol, present in grapes and other plants, is a polyphenolic compound with strong antioxidative activity. In our previous studies, we found that reactive oxygen species (ROS) accelerated the invasive capacity of a rat ascites hepatoma cell line of AH109A in culture and that resveratrol and resveratrol-loaded rat sera suppressed the ROS-potentiated invasion of the hepatoma cells. To study mechanisms by which resveratrol and its in vivo metabolite(s) suppress the invasion, we estimated intracellular peroxide level and expression of hepatocyte growth factor (HGF), a known cell motility factor, in AH109A cells. Exogenously added ROS promoted the intracellular peroxide level and the expression of HGF. Resveratrol and resveratrol-loaded rat sera canceled the rise in the peroxide level and HGF expression in ROS-stimulated tumor cells. These results suggest an involvement of the antioxidative property of resveratrol and sera from rats orally given resveratrol in their suppressive effects on ROS-potentiated invasion of AH109A cells.
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