ReviewTransgenic research2004
Lentiviral transgenesis.
Review in Transgenic research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- 2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research.Journal of cardiovascular translational research · 2015Guideline
- Germ-line transmission of lentiviral PGK-EGFP integrants in transgenic cattle: new perspectives for experimental embryology.Transgenic research · 2010Trial
- The Gq signalling pathway inhibits brown and beige adipose tissue.Nature communications · 2016Article
- Embryo development, fetal growth and postnatal phenotype of eGFP lambs generated by lentiviral transgenesis.Transgenic research · 2015Article
- Gene transfer into cardiac myocytes.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Vector modifications to eliminate transposase expression following piggyBac-mediated transgenesis.Scientific reports · 2014Article
- Establishment of cell lines with increased susceptibility to EV71/CA16 by stable overexpression of SCARB2.Virology journal · 2013Article
- Highly efficient generation of transgenic sheep by lentivirus accompanying the alteration of methylation status.PloS one · 2013Article
- Progress and prospects for genetic modification of nonhuman primate models in biomedical research.ILAR journal · 2013Review
- Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat.BMC immunology · 2012Article
- New routes for transgenesis of the mouse.Journal of applied genetics · 2012Review
- Stable silencing of β-lactoglobulin (BLG) gene by lentivirus-mediated RNAi in goat fetal fibroblasts.Genetics and molecular biology · 2012Article
- Skin-specifically transgenic expression of biologically active human cytoxic T-lymphocyte associated antigen4-immunoglobulin (hCTLA4Ig) in mice using lentiviral vector.Transgenic research · 2012Article
- Lentiviral transgenesis in livestock.Transgenic research · 2011Article
- A new method to efficiently produce transgenic embryos and mice from low-titer lentiviral vectors.Transgenic research · 2011Article
- Quantitative analysis of lentiviral transgene expression in mice over seven generations.Transgenic research · 2010Article
- Transgenic pigs as models for translational biomedical research.Journal of molecular medicine (Berlin, Germany) · 2010Review
- Induction of human blood group a antigen expression on mouse cells, using lentiviral gene transduction.Human gene therapy · 2010Article
- Beyond the rat models of human neurodegenerative disorders.Cellular and molecular neurobiology · 2009Review
- Transgenic mice and their impact on kidney research.Pflugers Archiv : European journal of physiology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transgenic animals are relevant for many fields of modern biomedicine and agriculture. However, the inefficiencies of the presently available techniques--DNA microinjection and retroviral gene transfer--have led to an explosion of costs for transgenics especially in farm animals. The recent success in transferring genes to early embryos of different species (mouse, rat, pig, cattle) by viral vectors derived from lentiviruses, has established lentiviral transgenesis as an exciting alternative to the classical method of DNA microinjection. In addition, lentiviral vectors can be used to transfer genes into embryonic stem cells. Due to its high efficacy and versatility, lentiviral transgenesis should have a big impact on transgenic research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.