ArticleMammalian genome : official journal of the International Mammalian Genome Society2004
A large-sample QTL study in mice: III. Reproduction.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Balanced selection on purebred and crossbred performance increases gain in crossbreds.Genetics, selection, evolution : GSE · 2018Article
- A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2.PLoS genetics · 2015Article
- Genome-wide association study identifies candidate genes for male fertility traits in humans.American journal of human genetics · 2012Article
- Genetic analysis in the Collaborative Cross breeding population.Genome research · 2011Article
- Genomic mapping of social behavior traits in a F2 cross derived from mice selectively bred for high aggression.BMC genetics · 2010Article
- Mapping interacting QTL for count phenotypes using hierarchical Poisson and binomial models: an application to reproductive traits in mice.Genetics research · 2010Article
- Article
- Bayesian mapping of genomewide interacting quantitative trait loci for ordinal traits.Genetics · 2007Article
- Centimorgan-range one-step mapping of fertility traits using interspecific recombinant congenic mice.Genetics · 2007Article
- Quantitative trait loci for body weight, condition factor and age at sexual maturation in Arctic charr (Salvelinus alpinus): comparative analysis with rainbow trout (Oncorhynchus mykiss) and Atlantic salmon (Salmo salar).Molecular genetics and genomics : MGG · 2007Article
- Overdominant quantitative trait loci for yield and fitness in tomato.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Identification of genetic regions of importance for reproductive performance in female mice.Genetics · 2006Article
- Genomic mapping of direct and correlated responses to long-term selection for rapid growth rate in mice.Genetics · 2005Article
- Relationships between quantitative and reproductive fitness traits in animals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
- A large-sample QTL study in mice: I. Growth.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- A large-sample QTL study in mice: II. Body composition.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using lines of mice having undergone long-term selection for high and low growth, a large-sample (n approximately to 1000 F2) experiment was conducted to gain further understanding of the genetic architecture of complex polygenic traits. Composite interval mapping on data from 10-week-old F2 females (n = 439) detected 15 quantitative trait loci (QTLs) on 5 chromosomes that influence reproduction traits characterized at day 16 of gestation. These QTL are broadly categorized into two groups: those where effects on the number of live fetuses (LF) were accompanied by parallel effects on the number of dead fetuses (DF), and those free of such undesirable effects. QTL for ovulation rate (OR) did not overlap with QTL for litter size, potentially indicating the importance of uterine capacity. Large dominance effects were identified for most QTL detected, and overdominance was also present. The QTL of largest effects were detected in regions of Chromosome 2, where large QTL effects for growth and fatness have also been found and where corroborating evidence from other studies exists. Considerable overlap between locations of QTL for reproductive traits and for growth traits corresponds well with the positive correlations usually observed among these sets of phenotypes. Some support for the relevance of QTL x genetic background interactions in reproduction was detected. Traits with low heritability demand considerably larger sample sizes to achieve effective power of QTL detection. This is unfortunate as traits with low heritability are among those that could most benefit from QTL-complemented breeding and selection strategies in food animal production.
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