ArticleInvestigative ophthalmology & visual science2005
Reduced visual function associated with infantile spasms in children on vigabatrin therapy.
Article in Investigative ophthalmology & visual science, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Review
- Infantile Spasms and West Syndrome - A Clinician's Perspective.Indian journal of pediatrics · 2020Review
- Retinal defect in children with infantile spasms of varying etiologies: An observational study.Neurology · 2020Observational
- The diagnosis and assessment of visual function in Singaporean children with electrophysiology: 10-year results.Documenta ophthalmologica. Advances in ophthalmology · 2016Article
- Review
- Safety and efficacy of vigabatrin for the treatment of infantile spasms.Journal of central nervous system disease · 2011Article
- Infantile spasms: review of the literature and personal experience.Italian journal of pediatrics · 2010Review
- Visual evoked potentials in succinate semialdehyde dehydrogenase (SSADH) deficiency.Journal of inherited metabolic disease · 2009Article
- Article
- Paradoxical robust visual evoked potentials in young patients with cortical blindness.Documenta ophthalmologica. Advances in ophthalmology · 2009Article
- Reduced grating acuity associated with retinal toxicity in children with infantile spasms on vigabatrin therapy.Investigative ophthalmology & visual science · 2009Article
- Bootstrap significance of low SNR evoked response.Journal of neuroscience methods · 2008Article
- A new generation of anticonvulsants for the treatment of epilepsy in children.Paediatrics & child health · 2007Article
- Contrast sensitivity is reduced in children with infantile spasms.Investigative ophthalmology & visual science · 2007Article
- Vigabatrin.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2007Review
- New generation anticonvulsants for the treatment of epilepsy in children.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics · 2006Review
- Effects of medications on the human electroretinogram: A comprehensive review.Survey of ophthalmologyReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo use visual evoked potential (VEP) testing to determine whether visual deficits are present in children with a history of vigabatrin use.
methodsContrast sensitivity and visual acuity were assessed by visual evoked potential testing and compared between 28 children (mean age, 4.90 +/- 4.92 years) with seizure disorders who had taken vigabatrin and 14 typically developing children (mean age, 3.14 +/- 1.70 years). Exclusion criteria were heritable eye disease, suspected cortical visual impairment, nystagmus, and prematurity >2 weeks. The effects of the following factors on contrast sensitivity and visual acuity were examined: type of seizure (infantile spasms versus other), ERG result, duration of vigabatrin therapy, cumulative dosage of vigabatrin, and other seizure medications (other versus no other medication).
resultsContrast sensitivity and visual acuity were reduced in vigabatrin-treated children with infantile spasms compared with vigabatrin-treated children with other seizure disorders and typically developing control subjects. The other factors examined had no significant effect on contrast sensitivity or visual acuity, with adjustment for seizure type.
conclusionsChildren with infantile spasms on vigabatrin may have compromised visual function, even in the absence of suspected cortical visual impairment. The children tested in the present study have reduced vision, probably associated with infantile spasms rather than vigabatrin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.