ArticleBiochemical and biophysical research communications2005
Down-regulation of UCRP and UBE2L6 in BRCA2 knocked-down human breast cells.
Article in Biochemical and biophysical research communications, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
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- ISG15 pathway knockdown reverses pancreatic cancer cell transformation and decreases murine pancreatic tumor growth via downregulation of PDL-1 expression.Cancer immunology, immunotherapy : CII · 2019Article
- Exploring the Molecular Mechanism of the Drug-Treated Breast Cancer Based on Gene Expression Microarray.Biomolecules · 2019Article
- Regulatory network reconstruction of five essential microRNAs for survival analysis in breast cancer by integrating miRNA and mRNA expression datasets.Functional & integrative genomics · 2019Article
- Furosine Induced Apoptosis by the Regulation of STAT1/STAT2 and UBA7/UBE2L6 Genes in HepG2 Cells.International journal of molecular sciences · 2018Article
- Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells.The Journal of pathology · 2014Article
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- Ubiquitin- and ubiquitin-like proteins-conjugating enzymes (E2s) in breast cancer.Molecular biology reports · 2013Article
- The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Down-regulation of 7SL RNA expression and impairment of vesicular protein transport pathways by Leishmania infection of macrophages.The Journal of biological chemistry · 2005Article
- Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells.The Journal of biological chemistry · 2005Article
- Negative regulation of the expressions of cytokeratins 8 and 19 by SLUG repressor protein in human breast cells.Biochemical and biophysical research communications · 2005Article
- Alternative initiation and splicing in dicer gene expression in human breast cells.Breast cancer research : BCR · 2005Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To understand the effects of the transient ablation of BRCA2 gene expression in dividing human breast cells, we transiently knocked down BRCA2 mRNA in HMEC and other cells. Microarray analysis of mRNAs revealed the down-regulation of the mRNAs of ubiquitin cross-reacting protein (UCRP) and the E2 enzyme that help conjugating UCRP to its target proteins, namely UBE2L6 (UbcH8), in BRCA2 ablated cells. UCRP is an interferon regulated protein, involved in cell growth and cell cycle events by participating in the degradation/modulation of cell cycle regulatory proteins. Quantitative-PCR and Northern analysis confirmed down-regulation of UCRP and UBE2L6 with BRCA2 knockdown, respectively. Since UCRP and UCRPylation have critical roles in the innate immunity against viral infection and during pregnancy, our observation may indicate new roles of the BRCA2 protein.
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