ArticleAnatomy and embryology1992
Expression and organization of muscle specific proteins during the early developmental stages of the rabbit heart.
Article in Anatomy and embryology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 36 citations in OpenAlex.
- Muscle giants: molecular scaffolds in sarcomerogenesis.Physiological reviews · 2009Review
- Dedifferentiation of atrial cardiomyocytes as a result of chronic atrial fibrillation.The American journal of pathology · 1997Article
- Development of cardiac musculature in the cranial vena cava of rat embryos.Anatomy and embryology · 1996Article
- Titin expression as an early indication of heart and skeletal muscle differentiation in vitro. Developmental re-organisation in relation to cytoskeletal constituents.Journal of muscle research and cell motility · 1996Article
- Alterations of heart development in Xenopus laevis by galactoside-binding lectin or its sugar hapten inhibitor.Anatomy and embryology · 1993Article
- Differentiation of human skeletal muscle cells in culture: maturation as indicated by titin and desmin striation.Cell and tissue research · 1992Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression and intracellular distribution patterns of muscle-specific proteins were studied during rabbit embryo development (7-13 dpc) using monoclonal antibodies against titin, myosin, tropomyosin and actin, as well as the intermediate filament proteins desmin, keratin and vimentin. From our panel, titin appeared to be the first muscle-specific protein to be exclusively expressed in the embryonic rabbit heart. Upon differentiation (myocyte and myotube formation), titin reorganizes from dot-like aggregates into a cross-striated pattern (in 9- to 30-somite embryos) via a transiently filamentous distribution. When the expression and organization of the other muscle proteins was studied in relation to titin, it became apparent that tropomyosin followed upon titin with respect to its exclusive expression in the heart anlagen and its organization into a striated pattern. Myosin and desmin were organized into cross-striated patterns after titin and tropomyosin, but this arrangement had not reached its final form in 13-dpc embryos. Actin, keratin and vimentin were distributed in cytoplasmic filaments in the embryonic stages we investigated. Since the first pulsations are already detected in 3-somite embryos, we conclude that the organization of titin, tropomyosin, myosin and desmin into a striated pattern does not seem to be essential for the initiation of muscle cell contraction in the heart anlagen. Furthermore, this study shows that, in comparison with studies on mouse, chick and rat, the sequence of expression of muscle-specific and intermediate filament proteins during cardiomyogenesis is species-dependent, and that their expression and organization varies in time in different regions of the developing heart.
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