Evidence map›Paper›PMID 15669150›Full record

Trial reportPharmacoEconomics2004

Follow-up lipid tests and physician visits are associated with improved adherence to statin therapy.

Joshua S Benner, Jonothan C Tierce, Christie M Ballantyne, Cheryl Prasad, Michael F Bullano, Vincent J Willey, John Erbey, David S Sugano

Abstract readClinical TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in PharmacoEconomics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 6 pooled it
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 6 syntheses or guidelines pooled it, 115 citations in OpenAlex.

  1. Guideline
  2. Prevalence of statin intolerance: a meta-analysis.European heart journal · 2022 · on this map
    Pooled it
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  8. A simple informative intervention in primary care increases statin adherence.European journal of clinical pharmacology · 2016 · on this map
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  15. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Joshua S BennerValueMedics Research, LLC, Arlington, Virginia, USA. josh.benner@ValueMedics.com
Jonothan C Tierce
Christie M Ballantyne
Cheryl Prasad
Michael F Bullano
Vincent J Willey
John Erbey
David S Sugano
Baylor College of Medicine · USUPMC Center for High Value Health Care · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION AND

objectiveThe National Cholesterol Education Program recommends regular physician follow-up and lipid testing to promote adherence with lipid-lowering medications. The objective of this study was to determine whether lipid tests and physician visits after treatment initiation are indeed associated with adherence to statin therapy. SUBJECTS AND

methodsA retrospective cohort study was conducted among 19 422 enrolees in a US managed care plan who initiated treatment with a statin between October 1999 and August 2001. Computerised pharmacy, medical and laboratory records were used to study the patterns and predictors of adherence with lipid-lowering therapy for up to 3 years. Adherence was assessed in 3-month intervals with patients considered 'adherent' if > or = 80% of days were covered by lipid-lowering therapy.

resultsIn the first 3 months, 40% of patients had follow-up lipid tests and only 21% had dyslipidaemia visits (14% had both). Those receiving such care were substantially more likely to be adherent in subsequent intervals. Compared with those without follow-up, the relative odds of adherence were 1.42 and 1.27 for patients with one or more lipid test and one or more dyslipidaemia visit, respectively (95% confidence intervals [CI] 1.33, 1.50 and 1.16, 1.39). Patients who received a follow-up visit and lipid test were 45% more likely to be adherent (95% CI 1.34, 1.55). Similar associations were observed when lipid tests and dyslipidaemia visits occurred later in therapy.

conclusionEarly and frequent follow-up by physicians--especially lipid testing--was associated with improved adherence to lipid-lowering therapy. A randomised prospective study is needed to determine whether this relationship is causal.

Indexed as

Physician-Patient RelationsAdolescentAdultAgedCohort StudiesCoronary DiseaseFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHyperlipidemiasLipidsMaleMiddle AgedMultivariate AnalysisPatient CompliancePractice Patterns, Physicians'Hydroxymethylglutaryl-CoA Reductase InhibitorsLipids

Identifiers

PMID15669150
OpenAlexW2058622522

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.