ArticleVirchows Archiv : an international journal of pathology2005
Immunohistochemical and cytogenetic characterization of acantholytic squamous cell carcinoma of the breast.
Article in Virchows Archiv : an international journal of pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 14 citations in OpenAlex.
- Acantholytic squamous cell carcinoma of the lung with pseudoglandular features: clinicopathologic study of 14 cases.Virchows Archiv : an international journal of pathology · 2025Article
- Acantholytic squamous cell carcinoma in upper aerodigestive tract: histopathology, immunohistochemical profile and epithelial mesenchymal transition phenotype change.Head and neck pathology · 2012Article
- Primary acantholytic squamous cell carcinoma of the cecum: a case report.Diagnostic pathology · 2011Article
- Acantholytic variant of squamous cell carcinoma of breast: a rare case report.Ecancermedicalscience · 2011Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
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Abstract
Primary acantholytic squamous cell carcinoma (ASCC) of the breast is a rare and aggressive variant of invasive breast cancer. Here we report two new cases of ASCC and their immunohistochemical and cytogenetic characterization. One case was associated with systemic metastases and death and the other with local failure prior to loss of follow-up. Using comparative genomic hybridization (CGH), both tumors showed a high overall number of chromosomal imbalances with a similar pattern of gains and losses. Genetic aberrations common to both tumors included losses at 3p11-p25, 5q21-q31, 8p, 9, 13p13-q21, 16q12-q21, and 17p and gains at 1q31-qter, 7p, 18q12-qter, 19q, and 20. Immunohistochemically, the tumors were characterized by high proliferative activity, an uncommon cytokeratin expression profile, reduced E-cadherin staining, and overexpression of p53 and epithelial growth factor receptor (EGFR). The results of our analyses suggest that genetic alterations observed in ASCC of the breast include imbalances commonly observed in both mammary adenocarcinoma and squamous cell carcinoma of other locations. Furthermore, the overexpressed EGFR could be a possible therapeutic target for individual cases of this aggressive tumor type.
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